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J-GLOBAL ID：201502208970961011   Reference number：15A1268287

Overexpression of salivary-type amylase reduces the sensitivity to bortezomib in multiple myeloma cells

唾液型アミラーゼの過剰発現は多発性骨髄腫細胞でボルテゾミブへの感受性を低下する

Author (17)： MIZUNO Shohei (Aichi Medical Univ., Div. of Hematology, Dep. of Internal Medicine, 1, 1 Karimata, Yazako, 480-1195, Nagakute, Aichi ...) ,  HANAMURA Ichiro (Aichi Medical Univ., Div. of Hematology, Dep. of Internal Medicine, 1, 1 Karimata, Yazako, 480-1195, Nagakute, Aichi ...) ,  OTA Akinobu (Aichi Medical Univ., Dep. of Biochemistry, Nagakute, Aichi, JPN) ,  KARNAN Sivasundaram (Aichi Medical Univ., Dep. of Biochemistry, Nagakute, Aichi, JPN) ,  NARITA Tomoko (Nagoya City Univ. Graduate School of Medical Sciences, Dep. of Hematology and Oncology, Nagoya, Aichi, JPN) ,  RI Masaki (Nagoya City Univ. Graduate School of Medical Sciences, Dep. of Hematology and Oncology, Nagoya, Aichi, JPN) ,  MIZUTANI Motonori (Aichi Medical Univ., Div. of Hematology, Dep. of Internal Medicine, 1, 1 Karimata, Yazako, 480-1195, Nagakute, Aichi ...) ,  GOTO Mineaki (Aichi Medical Univ., Div. of Hematology, Dep. of Internal Medicine, 1, 1 Karimata, Yazako, 480-1195, Nagakute, Aichi ...) ,  GOTOU Mayuko (Aichi Medical Univ., Div. of Hematology, Dep. of Internal Medicine, 1, 1 Karimata, Yazako, 480-1195, Nagakute, Aichi ...) ,  TSUNEKAWA Norikazu (Aichi Medical Univ., Div. of Hematology, Dep. of Internal Medicine, 1, 1 Karimata, Yazako, 480-1195, Nagakute, Aichi ...) ,  SHIKAMI Masato (Daiyukai General Hospital, Dep. of Hematology, Ichinomiya, Aichi, JPN) ,  IIDA Shinsuke (Nagoya City Univ. Graduate School of Medical Sciences, Dep. of Hematology and Oncology, Nagoya, Aichi, JPN) ,  HOSOKAWA Yoshitaka (Aichi Medical Univ., Dep. of Biochemistry, Nagakute, Aichi, JPN) ,  MIWA Hiroshi (Toyama Hospital, Dep. of Internal Medicine, Tsu, Mie, JPN) ,  UEDA Ryuzo (Aichi Medical Univ., Dep. of Tumor Immunology, Nagakute, Aichi, JPN) ,  NITTA Masakazu (Aichi Medical Univ., Div. of Hematology, Dep. of Internal Medicine, 1, 1 Karimata, Yazako, 480-1195, Nagakute, Aichi ...) ,  TAKAMI Akiyoshi (Aichi Medical Univ., Div. of Hematology, Dep. of Internal Medicine, 1, 1 Karimata, Yazako, 480-1195, Nagakute, Aichi ...)
Material： International Journal of Hematology  (Int J Hematol)
Volume： 102  Issue： 5  Page： 569-578  Publication year： Nov. 2015 
JST Material Number： F0888A  ISSN： 0925-5710  CODEN： IJHEEY  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *alpha-amylase ,...
Semi thesaurus term： 8226/AMY1細胞 ,...

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JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Blood cell tumors(=neoplasms)  (GK04000M)

Substance index (1)： Bortezomib

Reference (25)：

• Ludwig H, Sonneveld P, Davies F, Bladé J, Boccadoro M, Cavo M, et al. European perspective on multiple myeloma treatment strategies in 2014. Oncologist. 2014;19:829-44.
• Watanabe R, Tokuhira M, Kizaki M. Current approaches for the treatment of multiple myeloma. Int J Hematol. 2013;97:333-44.
• Hata H, Matsuzaki H, Tanaka K, Nomura H, Kagimoto T, Takeya M, et al. Ectopic production of salivary-type amylase by a IgA-lambda-type multiple myeloma. Cancer. 1988;62:1511-5.
• Matsuzaki H, Takatsuki K. Amylase producing multiple myeloma. Blood. 1989;74:889.
• Tagawa S, Doi S, Taniwaki M, Abe T, Kanayama Y, Nojima J, et al. Amylase-producing plasmacytoma cell lines, AD3 and FR4, with der(14)t(8;14) and dic(8)t(1;8) established from ascites. Leukemia. 1990;4:600-5.

Terms in the title (7)： 唾液 ,  アミラーゼ ,  過剰発現 ,  多発性骨髄腫 ,  細胞 ,  ボルテゾミブ ,  感受性