Art

J-GLOBAL ID：201502209247764964   Reference number：15A0866130

Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c

Kcnp1座位での父方アレル突然変異はCdkn1cのエピジェネティック修飾により膵β細胞量を減少させる

Author (24)： ASAHARA Shun-ichiro (Kobe Univ. Graduate School of Medicine, Hyogo, JPN) ,  ETOH Hiroaki (Kobe Univ. Graduate School of Medicine, Hyogo, JPN) ,  INOUE Hiroyuki (Kobe Univ. Graduate School of Medicine, Hyogo, JPN) ,  TERUYAMA Kyoko (Kobe Univ. Graduate School of Medicine, Hyogo, JPN) ,  SHIBUTANI Yuki (Kobe Univ. Graduate School of Medicine, Hyogo, JPN) ,  IHARA Yuka (Kobe Univ. Graduate School of Medicine, Hyogo, JPN) ,  KAWADA Yukina (Kobe Univ. Graduate School of Medicine, Hyogo, JPN) ,  BARTOLOME Alberto (Kobe Univ. Graduate School of Medicine, Hyogo, JPN) ,  HASHIMOTO Naoko (Kobe Univ. Graduate School of Medicine, Hyogo, JPN) ,  MATSUDA Tomokazu (Kobe Univ. Graduate School of Medicine, Hyogo, JPN) ,  KOYANAGI-KIMURA Maki (Kobe Univ. Graduate School of Medicine, Hyogo, JPN) ,  KANNO Ayumi (Kobe Univ. Graduate School of Medicine, Hyogo, JPN) ,  HIROTA Yushi (Kobe Univ. Graduate School of Medicine, Hyogo, JPN) ,  HOSOOKA Tetsuya (Kobe Univ. Graduate School of Medicine, Hyogo, JPN) ,  NAGASHIMA Kazuaki (Kyoto Univ., Kyoto, JPN) ,  NISHIMURA Wataru (Jichi Medical Univ., Tochigi, JPN) ,  INOUE Hiroshi (Kanazawa Univ., Ishikawa, JPN) ,  MATSUMOTO Michihiro (National Center for Global Health and Medicine, Tokyo, JPN) ,  HIGGINS Michael J. (Roswell Park Cancer Inst., NY) ,  YASUDA Kazuki (National Center for Global Health and Medicine, Tokyo, JPN) ,  INAGAKI Nobuya (Kyoto Univ., Kyoto, JPN) ,  SEINO Susumu (Kobe Univ. Graduate School of Medicine, Hyogo, JPN) ,  KASUGA Masato (National Center for Global Health and Medicine, Tokyo, JPN) ,  KIDO Yoshiaki (Kobe Univ. Graduate School of Medicine, Hyogo, JPN)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 112  Issue： 27  Page： 8332-8337  Publication year： Jul. 07, 2015 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *endocrine cell ,  gene ,  mutation ,  *epigenetics ,  imprinting ,  potassium channel ,  type 2 diabetes mellitus ,  RNA ,  protein ,  *cell cycle
Semi thesaurus term： Cdkn1c ,  *Kcnp1 ,  KCNQ1 Potassium Channel ,  imprinting ,  epigenetic ,  細胞周期阻害因子 ,  noncoding RNA ,  *父方アレル突然変異 ,  *pancreatic beta cell

JST classification (4)： Genetic variation  (EC01030Y) ,  Gene expression  (EC02040Q) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Pancreas  (EJ06050Y)

Terms in the title (6)： 座位 ,  アレル ,  突然変異 ,  エピジェネティック ,  修飾 ,  膵β細胞