Art

J-GLOBAL ID：201502210577643231   Reference number：15A1348542

Estimation of Internal Radiation Dose in Human Based on Animal Data-Application of Methodology in Drug Metabolism and Pharmacokinetics-

動物データに基づくヒト放射線内部被ばく線量の評価-薬物動態学的方法論の応用-

Author (6)： SUGIMOTO TOMONORI ,  IWASE YUMIKO ,  YUMITA NAGAHIKO ,  CHIBA KOJI ,  YAMAZAKI HIROSHI ,  IKEDA TOSHIHIKO
Material： Radioisotopes
Volume： 64  Issue： 11  Page： 673-679 (J-STAGE)  Publication year： 2015 
JST Material Number： G0494A  ISSN： 0033-8303  CODEN： RAISAB  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *internal exposure ,...
Semi thesaurus term： 動物データ

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JST classification (1)： Contamination of man and its prevention  (MB02020Z)

Reference (4)：

• 1) Stabin, M. G., Sparks, R. B. and Crowe, E., OLINDA/EXM:the second-generation personal computer software for internal dose assessment in nuclear medicine, J. Nucl. Med., 46, 1023-1027(2005)
• 2) Ikeda, T., Aoyama, S., Tozuka, Z., Nozawa, K., Hamabe, Y., Matsui, T., Kainuma, M., Hasegawa, S., Maeda, K. and Sugiyama, Y., Microdose pharmacogenetic study of ¹⁴C-tolbutamide in healthy subjects with accelerator mass spectrometry to examine the effects of CYP2C9*3 on its pharmacokinetics and metabolism, Eur. J. Pharm. Sci., 49, 642-648(2013)
• 3) Tozuka, Z., Kusuhara, H., Nozawa, K., Hamabe, Y., Ikushima, I., Ikeda, T. and Sugiyama, Y., Microdose study of ¹⁴C-acetaminophen with accelerator mass spectrometry to examine pharmacokinetics of parent drug and metabolites in healthy subjects, Clin. Pharmacol. Ther., 88, 824-830(2010)
• 4) Yamazaki, H., Kunikane, E., Nishiyama, S., Murayama, N., Shimizu, M., Sugiyama, Y., Chiba, K. and Ikeda, T., Human plasma concentrations of tolbutamide and acetaminophen extrapolated from in vivo animal pharmacokinetics using in vitro human hepatic clearances and simple physiologically based pharmacokinetic modeling for radio-labeled microdose clinical studies, RADIOISOTOPES, 64, 509-519(2015)

Terms in the title (7)： 動物 ,  ヒト ,  放射線内部被ばく ,  線量 ,  評価 ,  薬物動態学 ,  応用