Art

J-GLOBAL ID：201502211815979444   Reference number：15A0850849

Influence of 4′-O-Glycoside Constitution and Configuration on Ribosomal Selectivity of Paromomycin

パロモマイシンのリボソーム選択性に及ぼす4′-O′-グリコシド構成および構造の影響

Author (8)： MATSUSHITA Takahiko (Wayne State Univ., Michigan, USA) ,  CHEN Weiwei (Wayne State Univ., Michigan, USA) ,  JUSKEVICIENE Reda (Univ. Zuerich, Zuerich, CHE) ,  TEO Youjin (Univ. Zuerich, Zuerich, CHE) ,  SHCHERBAKOV Dimitri (Univ. Zuerich, Zuerich, CHE) ,  VASELLA Andrea (ETH Zuerich, Zuerich, CHE) ,  BOETTGER Erik C. (Univ. Zuerich, Zuerich, CHE) ,  CRICH David (Wayne State Univ., Michigan, USA)
Material： Journal of the American Chemical Society  (J Am Chem Soc)
Volume： 137  Issue： 24  Page： 7706-7717  Publication year： Jun. 24, 2015 
JST Material Number： C0254A  ISSN： 0002-7863  CODEN： JACSAT  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *aminoglycoside antibiotics ,  amebacide ,  deoxysugar ,  glucoside ,  bacterium ,  mitochondria ,  cytosol ,  ribosome ,  biological activity ,  space structure ,  MRSA ,  pathogen ,  antibacterial action ,  *structure-activity relationship ,  amino sugar ,  alditol ,  pyranoside ,  secondary amine ,  oligosaccharide ,  furanoside
Semi thesaurus term： antibacterial activity ,  cytosol ,  Protein Synthesis Inhibitors ,  pathogenic bacteria

JST classification (1)： Basic research of antibiotics acting on pathogenic organisms  (GX05020C)

Substance index (14)： Apramycin ,  Paromomycin ,  2α-(4-O-Ethyl-2-amino-2-deoxy-α-D-glucopyranosyloxy)-3β,5β-diamino-6α-hydroxycyclohexane-1β-yl 3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)β-D-ribofuranoside ,  2α-(4-O-Propyl-2-amino-2-deoxy-α-D-glucopyranosyloxy)-3β,5β-diamino-6α-hydroxycyclohexane-1β-yl 3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)β-D-ribofuranoside ,  2α-(4-O-(2-Hydroxyethyl)-2-amino-2-deoxy-α-D-glucopyranosyloxy)-3β,5β-diamino-6α-hydroxycyclohexane-1β-yl 3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)β-D-ribofuranoside ,  2α-(4-O-(α-D-Glucopyranosyl)-2-amino-2-deoxy-α-D-glucopyranosyloxy)-3β,5β-diamino-6α-hydroxycyclohexane-1β-yl 3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)β-D-ribofuranoside ,  2α-(4-O-(β-D-Glucopyranosyl)-2-amino-2-deoxy-α-D-glucopyranosyloxy)-3β,5β-diamino-6α-hydroxycyclohexane-1β-yl 3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)β-D-ribofuranoside ,  2α-(4-O-(α-D-Mannopyranosyl)-2-amino-2-deoxy-α-D-glucopyranosyloxy)-3β,5β-diamino-6α-hydroxycyclohexane-1β-yl 3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)β-D-ribofuranoside ,  2α-(4-O-(β-D-Mannopyranosyl)-2-amino-2-deoxy-α-D-glucopyranosyloxy)-3β,5β-diamino-6α-hydroxycyclohexane-1β-yl 3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)β-D-ribofuranoside ,  2α-(4-O-(α-D-Galactopyranosyl)-2-amino-2-deoxy-α-D-glucopyranosyloxy)-3β,5β-diamino-6α-hydroxycyclohexane-1β-yl 3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)β-D-ribofuranoside ,  2α-(4-O-(β-D-Galactopyranosyl)-2-amino-2-deoxy-α-D-glucopyranosyloxy)-3β,5β-diamino-6α-hydroxycyclohexane-1β-yl 3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)β-D-ribofuranoside ,  2α-(4-O-(4-Amino-4-deoxy-α-D-glucopyranosyl)-2-amino-2-deoxy-α-D-glucopyranosyloxy)-3β,5β-diamino-6α-hydroxycyclohexane-1β-yl 3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)β-D-ribofuranoside ,  2α-(4-O-(4-Amino-4-deoxy-β-D-glucopyranosyl)-2-amino-2-deoxy-α-D-glucopyranosyloxy)-3β,5β-diamino-6α-hydroxycyclohexane-1β-yl 3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)β-D-ribofuranoside ,  2α-(4-O-(α-D-Glucopyranosyloxymethyl)-2-amino-2-deoxy-α-D-glucopyranosyloxy)-3β,5β-diamino-6α-hydroxycyclohexane-1β-yl 3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)β-D-ribofuranoside

Terms in the title (4)： パロモマイシン ,  リボソーム ,  選択性 ,  グリコシド