Art

J-GLOBAL ID：201502213030385440   Reference number：15A0816881

Farnesoid X receptor knockdown provides significant growth inhibition in hepatocellular carcinoma cells while it does not interfere with the proliferation of primary human hepatocyte-derived cells

ファルネソイドX受容体のノックダウンは肝細胞癌細胞の顕著な成長抑制をもたらすが,その一方でヒト一次肝由来細胞の増殖を妨害しない

Author (8)： FUJINO Tomofumi (Dep. of Hygiene and Health Sciences, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  MARUKO-OHTAKE Akiko (Dep. of Radiopharmacy, Tohoku Pharmaceutical Univ.) ,  OHTAKE Yosuke (Dep. of Radiopharmacy, Tohoku Pharmaceutical Univ.) ,  KOBAYASHI Tomonori (Dep. of Radiopharmacy, Tohoku Pharmaceutical Univ.) ,  ANDO Ken (Dep. of Hygiene and Health Sciences, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  TAKEUCHI Airi (Dep. of Hygiene and Health Sciences, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences) ,  OHKUBO Yasuhito (Dep. of Radiopharmacy, Tohoku Pharmaceutical Univ.) ,  HAYAKAWA Makio (Dep. of Hygiene and Health Sciences, School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sciences)
Material： Journal of Toxicological Sciences  (日本毒性学会学術年会プログラム・要旨集)
Volume： 40  Issue： 4  Page： 501-508 (J-STAGE)  Publication year： 2015 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *enzyme inhibitor ,...
Semi thesaurus term： *cytosol receptor ,...

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JST classification (5)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Tumors(=neoplasms)of digestive system  (GH04000D) ,  Gene expression  (EC02040Q) ,  Biological function  (EB03040U) ,  Cell division and proliferation  (EF02020D)

Reference (14)：

• Chen, X., Barton, L.F., Chi, Y., Clurman, B.E. and Roberts, J.M. (2007): Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome. Mol. Cell, 26, 843-852.
• Fujino, T., Takeuchi, A., Maruko-Ohtake, A., Ohtake, Y., Satoh, J., Kobayashi, T., Tanaka, T., Ito, H., Sakamaki, R., Kashimura, R., Ando, K., Nishimaki-Mogami, T., Ohkubo, Y., Kitamura, N., Sato, R., Kikugawa, K. and Hayakawa, M. (2012): Critical role of farnesoid X receptor for hepatocellular carcinoma cell proliferation. J. Biochem., 152, 577-586.
• Han, J., Kim, Y.-L., Lee, K.-W., Her, N.-G., Ha, T.-K., Yoon, S., Jeong, S.-I., Lee, J.-H., Kang, M.-J., Lee, M.-G., Ryu, B.-K., Baik, J.-H. and Chi, S.-G. (2013): ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21^WAF1. Cell Death Differ., 20, 1055-1067.
• Lee, D.H. and Goldberg, A.L. (1998): Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol., 8, 397-403.
• Lew, J.L., Zhao, A., Yu, J., Huang, L., De Pedro, N., Peláez, F., Wright, S.D. and Cui, J. (2004): The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion. J. Biol. Chem., 279, 8856-8861.

Terms in the title (10)： ファルネソイドX受容体 ,  ノックダウン ,  肝細胞 ,  癌細胞 ,  成長抑制 ,  ヒト ,  肝 ,  細胞 ,  増殖 ,  妨害