Art

J-GLOBAL ID：201502214032387879   Reference number：15A0457520

Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors

新規低酸素誘導因子(HIF)-1阻害剤としての1-エチルピラゾール-3-カルボキサミド化合物の設計,合成,および構造活性相関

Author (9)： YASUDA Yorinobu (Dep. of System Chemotherapy and Molecular Sciences, Div. of Bioinformatics and Chemical Genomics, Graduate School of ...) ,  ARAKAWA Takeaki (Dep. of System Chemotherapy and Molecular Sciences, Div. of Bioinformatics and Chemical Genomics, Graduate School of ...) ,  NAWATA Yumi (Dep. of System Chemotherapy and Molecular Sciences, Div. of Bioinformatics and Chemical Genomics, Graduate School of ...) ,  SHIMADA Sayaka (Dep. of System Chemotherapy and Molecular Sciences, Div. of Bioinformatics and Chemical Genomics, Graduate School of ...) ,  OISHI Shinya (Dep. of Bioorganic Medicinal Chemistry & Chemogenomics, Div. of Bioinformatics and Chemical Genomics, Graduate ...) ,  FUJII Nobutaka (Dep. of Bioorganic Medicinal Chemistry & Chemogenomics, Div. of Bioinformatics and Chemical Genomics, Graduate ...) ,  NISHIMURA Shinichi (Dep. of System Chemotherapy and Molecular Sciences, Div. of Bioinformatics and Chemical Genomics, Graduate School of ...) ,  HATTORI Akira (Dep. of System Chemotherapy and Molecular Sciences, Div. of Bioinformatics and Chemical Genomics, Graduate School of ...) ,  KAKEYA Hideaki (Dep. of System Chemotherapy and Molecular Sciences, Div. of Bioinformatics and Chemical Genomics, Graduate School of ...)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 23  Issue： 8  Page： 1776-1787  Publication year： Apr. 15, 2015 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *DNA binding protein ,  *transcription factor ,  *drug ,  *drug design ,  *chemical synthesis ,  *Structure-Activity Relationship ,  drug therapy ,  bioassay ,  screening (inspection) ,  tumor cell ,  cultured cell ,  carbonic anhydrase ,  gene expression ,  cell migration ,  oxygen deficiency ,  antitumor drug ,  inhibition of multiplication ,  inhibition ,  polymerase chain reaction ,  HT1080 cell ,  Carbonic Anhydrase IX ,  inhibition of transcription ,  *Hypoxia-Inducible Factor 1 ,  molecular genetic phenomenon
Semi thesaurus term： *HIF1 ,  reporter gene assay ,  cancer chemotherapy ,  *inhibitor ,  創傷治癒アッセイ

JST classification (3)： Structure-activity relationship of drugs  (GV01050B) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic oncology in general  (GE02010R)

Substance index (2)： CLB-016 ,  N-(1-Ethyl-3-carbamoyl-1H-pyrazole-4-yl)-5-[(4-bromo-3,5-dimethyl-1H-pyrazole-1-yl)methyl]-2-furancarboxamide

Terms in the title (7)： 低酸素誘導因子 ,  HIF ,  阻害剤 ,  ピラゾール ,  カルボキサミド化合物 ,  設計 ,  構造活性相関