Art

J-GLOBAL ID：201502214199341154   Reference number：15A1269704

Simple and efficient isolation of cordycepin from culture broth of a Cordyceps militaris mutant

Cordyceps militaris変異体の培養液からコルジセピンの簡便で効率的な単離

Author (6)： MASUDA Mina (Dep. of Applied Chemistry and Biotechnology, Graduate School of Engineering, Univ. of Fukui, 3-9-1 Bunkyo, Fukui-shi ...) ,  HATASHITA Masanori (Res. & Dev. Dep., The Wakasa-wan Res. Center, 64-52-1 Nagatani, Tsuruga-shi, Fukui 914-0192, JPN) ,  FUJIHARA Shinya (Dep. of Applied Chemistry and Biotechnology, Graduate School of Engineering, Univ. of Fukui, 3-9-1 Bunkyo, Fukui-shi ...) ,  SUZUKI Yu (Tenure-Track Program for Innovative Res., Univ. of Fukui, 3-9-1 Bunkyo, Fukui-shi, Fukui 910-8507, JPN) ,  SAKURAI Akihiko (Dep. of Applied Chemistry and Biotechnology, Graduate School of Engineering, Univ. of Fukui, 3-9-1 Bunkyo, Fukui-shi ...) ,  SAKURAI Akihiko (Translational Res. Center, Organization for Life Sci. Advancement Programs, Univ. of Fukui, 23-3 Matsuokashimoaizuki ...)
Material： Journal of Bioscience and Bioengineering
Volume： 120  Issue： 6  Page： 732-735  Publication year： Dec. 2015 
JST Material Number： G0535B  ISSN： 1389-1723  CODEN： JBBIF6  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *fermented mash ,...
Semi thesaurus term： *Clavicipitales

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JST classification (2)： Microorganism biochemistry  (EG03020N) ,  Research methods in biological sciences in general  (EA03010K)

Substance index (1)： Cordycepine

Reference (17)：

• Cunningham, K. G., Manson, W., Spring, F. S., and Hutchinson, S. A.: Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris (Linn.) Link, Nature, 166, 949 (1950).
• Kodama, E. N., McCaffrey, R. P., Yusa, K., and Mitsuya, H.: Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells, Biochem. Pharmacol., 59, 273-281 (2000).
• Jeong, J.-W., Jin, C.-Y., Park, C., Han, M. H., Kim, G.-Y., Moon, S.-K., Kim, C. G., Jeong, Y. K., Kim, W.-J., Lee, J.-D., and Choi, Y. H.: Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt, Int. J. Oncol., 40, 1697-1704 (2012).
• Jeong, M.-H., Seo, M. J., Park, J. U., Kang, B. W., Kim, K.-S., Lee, J. Y., Kim, G.-Y., Kim, J.-I., Choi, Y. H., Kim, K. H., and Jeong, Y. K.: Effect of cordycepin purified from Cordyceps militaris on Th1 and Th2 cytokines in mouse splenocytes, J. Microbiol. Biotechnol., 22, 1161-1164 (2012).
• Kim, H. G., Shrestha, B., Lim, S. Y., Yoon, D. H., Chang, W. C., Shin, D.-J., Han, S. K., Park, S. M., Park, J. H., Park, H. I., and other 5 authors: Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-κB through Akt and p38 inhibition in RAW 264.7 macrophage cells, Eur. J. Pharmacol., 545, 192-199 (2006).

Terms in the title (6)： Cordyceps ,  変異体 ,  培養液 ,  コルジセピン ,  簡便 ,  単離