Art

J-GLOBAL ID：201502215532236114   Reference number：15A0876697

Dermal delivery of HSP47 siRNA with NOX4-modulating mesoporous silica-based nanoparticles for treating fibrosis

線維症を治療するためのNox4調節メソポーラスシリカ系ナノ粒子を用いるHSP47 siRNAの皮膚送達

Author (10)： MORRY Jingga (Dep. of Biomedical Engineering, Oregon Health and Sci. Univ., 3303 SW Bond Ave, Portland, OR 97239, USA) ,  NGAMCHERDTRAKUL Worapol (Dep. of Biomedical Engineering, Oregon Health and Sci. Univ., 3303 SW Bond Ave, Portland, OR 97239, USA) ,  GU Shenda (Dep. of Biomedical Engineering, Oregon Health and Sci. Univ., 3303 SW Bond Ave, Portland, OR 97239, USA) ,  GOODYEAR Shaun M. (Dep. of Biomedical Engineering, Oregon Health and Sci. Univ., 3303 SW Bond Ave, Portland, OR 97239, USA) ,  CASTRO David J. (Dep. of Biomedical Engineering, Oregon Health and Sci. Univ., 3303 SW Bond Ave, Portland, OR 97239, USA) ,  CASTRO David J. (PDX Pharmaceuticals, LLC, 24 Independence Ave, Lake Oswego, OR 97035, USA) ,  REDA Moataz M. (Dep. of Biomedical Engineering, Oregon Health and Sci. Univ., 3303 SW Bond Ave, Portland, OR 97239, USA) ,  SANGVANICH Thanapon (Dep. of Biomedical Engineering, Oregon Health and Sci. Univ., 3303 SW Bond Ave, Portland, OR 97239, USA) ,  YANTASEE Wassana (Dep. of Biomedical Engineering, Oregon Health and Sci. Univ., 3303 SW Bond Ave, Portland, OR 97239, USA) ,  YANTASEE Wassana (PDX Pharmaceuticals, LLC, 24 Independence Ave, Lake Oswego, OR 97035, USA)
Material： Biomaterials
Volume： 66  Page： 41-52  Publication year： Oct. 2015 
JST Material Number： C0964B  ISSN： 0142-9612  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *fibrous disease ,  *NADPH oxidase ,  *silicon dioxide ,  *nano particle ,  *siRNA ,  *chaperone protein ,  *serpin ,  *heat shock protein ,  gene introduction ,  *scleroderma ,  oxidative stress ,  Up-Regulation ,  gene expression ,  protein synthesis ,  Polyethyleneimine ,  polyethylene oxide ,  TGF beta ,  fibroblast ,  model ,  active oxygen ,  activity (property) ,  actin ,  Collagen ,  Mus musculus ,  fatty acid ,  aliphatic amine ,  thiol ,  carboxamide ,  sulfur containing amino acid ,  *HSP47 ,  In vitro model ,  Collagen synthesis ,  *silica nanoparticle ,  *mesoporous silica ,  antioxidant activity ,  *NADPH oxidase 4 ,  alpha SMA ,  Collagen Type I ,  *enzyme inhibitor ,  *proteinase inhibitor ,  molecular genetic phenomenon ,  Scleroproteins ,  animal protein ,  Myomorpha
Semi thesaurus term： *Nox4 ,  alpha SMA ,  Collagen Type I ,  polyethylene glycol ,  gene delivery ,  Reactive Oxygen Species ,  upregulation

JST classification (4)： Medical materials  (GA05040H) ,  Skin diseases  (GF03000Q) ,  Drug therapy(=pharmacotherapy)for skin diseases  (GF05020A) ,  Biological function  (EB03040U)

Substance index (1)： Acetylcysteine

Terms in the title (10)： 線維症 ,  治療 ,  Nox4 ,  調節 ,  メソポーラスシリカ ,  ナノ粒子 ,  HSP47 ,  siRNA ,  皮膚 ,  送達