Art

J-GLOBAL ID：201502215783591673   Reference number：15A0980527

Levobupivacaine induces vasoconstriction via Ca²⁺-dependent and -independent mechanisms in isolated rat thoracic aorta

レボブピバカインはラット摘出胸部大動脈片においてカルシウム依存性及び非依存性機構を介して血管収縮を誘導する

Author (5)： MUKOZAWA Mai (Dep. of Anesthesiology, Asahi Univ. School of Dentistry) ,  TAKAKURA Ko (Dep. of Anesthesiology and Reanimatology, Fac. of Medical Sciences, Fukui Univ.) ,  OBATA Yurie (Dep. of Anesthesiology and Reanimatology, Fac. of Medical Sciences, Fukui Univ.) ,  SHIMO Koichi (Dep. of Anesthesiology and Reanimatology, Fac. of Medical Sciences, Fukui Univ.) ,  SHIGEMI Kenji (Dep. of Anesthesiology and Reanimatology, Fac. of Medical Sciences, Fukui Univ.)
Material： 循環制御(Web)  (Circulation Control (Web))
Volume： 34  Issue： 1-3  Page： 71-77 (J-STAGE)  Publication year： 2013 
JST Material Number： U0641A  ISSN： 0389-1844  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *local anesthetic ,...

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JST classification (2)： Basic research of local anesthetics  (GW04020S) ,  Basic medicine on cardiovascular system  (GJ01020K)

Substance index (1)： Levobupivacaine

Reference (31)：

• Akata T: Cellular and molecular mechanisms regulating vascular tone. Part 1: basic mechanisms controlling cytosolic Ca²⁺ concentration and the Ca²⁺-dependent regulation of vascular tone. J Anesth 2007; 21: 220-31.
• Lee YR, Lee CK, Park HJ, et al: c-Jun N-terminal kinase contributes to norepinephrine-induced contraction through phosphorylation of caldesmon in rat aortic smooth muscle. J Pharmacol Sci 2006; 100: 119-25.
• Aps C, Reynolds F: The effect of concentration on vasoactivity of bupivacaine and lignocaine. Br J Anaesth 1976; 48: 1171-4.
• Johns RA, Seyde WC, DiFazio CA, et al: Dose-dependent effects of bupivacaine on rat muscle arterioles. Anesthesiology 1986; 65: 186-91.
• Ida H, Watanabe Y, Dohi S, et al: Direct effects of ropivacaine and bupivacaineon spinal pial vessels in canine. Anesthesiology 1997; 87: 75-81.

Terms in the title (9)： レボブピバカイン ,  ラット ,  摘出 ,  胸部大動脈 ,  カルシウム ,  依存性 ,  非依存性 ,  血管収縮 ,  誘導