Art

J-GLOBAL ID：201502216543336531   Reference number：15A0756091

Decreased expression of Runx1 and lowered proportion of Foxp3⁺CD25⁺CD4⁺ regulatory T cells in systemic sclerosis

全身性硬化症におけるFoxp3⁺CD25⁺CD4⁺制御性T細胞のRunx1の発現低下と集団の減少

Author (7)： KATAOKA Hiroshi (Hokkaido Univ. Graduate School of Medicine, Sapporo, JPN) ,  YASUDA Shinsuke (Hokkaido Univ. Graduate School of Medicine, Sapporo, JPN) ,  FUKAYA Shinji (Hokkaido Univ. Graduate School of Medicine, Sapporo, JPN) ,  OKU Kenji (Hokkaido Univ. Graduate School of Medicine, Sapporo, JPN) ,  HORITA Tetsuya (Hokkaido Univ. Graduate School of Medicine, Sapporo, JPN) ,  ATSUMI Tatsuya (Hokkaido Univ. Graduate School of Medicine, Sapporo, JPN) ,  KOIKE Takao (Hokkaido Univ. Graduate School of Medicine, Sapporo, JPN)
Material： Modern Rheumatology  (Mod Rheumatol)
Volume： 25  Issue： 1  Page： 90-95  Publication year： Jan. 2015 
JST Material Number： L5142A  ISSN： 1439-7595  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： *Runx1 ,...

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JST classification (1)： Cryptogenic diseases,other diseases in general  (GD07010X)

Reference (32)：

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• Helms C, Cao L, Krueger JG, Wijsman EM, Chamian F, Gordon D, et al. A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Nat Genet. 2003;35(4):349-56.
• Ono M, Yaguchi H, Ohkura N, Kitabayashi I, Nagamura Y, Nomura T, et al. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature. 2007;446(7136):685-9.
• Rudra D, Egawa T, Chong MM, Treuting P, Littman DR, Rudensky AY. Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells. Nat Immunol. 2009;10(11):1170-7.

Terms in the title (5)： 全身性硬化症 ,  制御性T細胞 ,  RUNX1 ,  発現 ,  集団