Art

J-GLOBAL ID：201502218146547589   Reference number：15A0903226

Generation of specific monoclonal antibodies against the extracellular loops of human claudin-3 by immunizing mice with target-expressing cells

マウスの標的発現細胞免疫化によるヒトクラウジン3の細胞外ループに対する特異的モノクロナール抗体生成また

Author (8)： ANDO Hiroshi (Kyowa Hakko Kirin Co., Ltd, Machida-shi, JPN) ,  SUZUKI Masayo (Kyowa Hakko Kirin Co., Ltd, Machida-shi, JPN) ,  KATO-NAKANO Mariko (Kyowa Hakko Kirin Co., Ltd, Machida-shi, JPN) ,  KAWAMOTO Shinobu (Kyowa Hakko Kirin Co., Ltd, Machida-shi, JPN) ,  MISAKA Hirofumi (Kyowa Hakko Kirin Co., Ltd, Shizuoka, JPN) ,  KIMOTO Naoya (Kyowa Hakko Kirin Co., Ltd, Shizuoka, JPN) ,  FURUYA Akiko (Kyowa Hakko Kirin Co., Ltd, Machida-shi, JPN) ,  NAKAMURA Kazuyasu (Kyowa Hakko Kirin Co., Ltd, Machida-shi, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 79  Issue： 8  Page： 1272-1279  Publication year： Aug. 2015 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： cell component ,...

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JST classification (2)： Biochemistry of antigens,antibodies,complements  (ED04020L) ,  Cell physiology in general  (EF02010S)

Reference (18)：

• Günzel D, Yu AS. Claudins and the modulation of tight junction permeability. Physiol. Rev. 2013;93:525-569.
• Offner S, Hekele A, Teichmann U, Weinberger S, Gross S, Kufer P, Itin C, Baeuerle PA, Kohleisen B. Epithelial tight junction proteins as potential antibody targets for pancarcinoma therapy. Cancer Immunol. Immunother. 2005;54:431-445.
• English DP, Santin AD. Claudins over expression in ovarian cancer: potential targets for Clostridium perfringens enterotoxin (CPE) based diagnosis and therapy. Int. J. Mol. Sci. 2013;14:10412-10437.
• Kwon MJ. Emerging roles of claudins in human cancer. Int. J. Mol. Sci. 2013;14:18148-18180.
• Okugawa T, Oshima T, Chen X, Hori K, Tomita T, Fukui H, Watari J, Matsumoto T, Miwa H. Down-regulation of claudin-3 is associated with proliferative potential in early gastric cancers. Dig. Dis. Sci. 2012;57:1562-1567.

Terms in the title (8)： マウス ,  標的 ,  発現 ,  細胞免疫 ,  ヒト ,  クラウジン3 ,  ループ ,  モノクロナール抗体