Art

J-GLOBAL ID：201502218355576340   Reference number：15A1092368

The R3 receptor-like protein tyrosine phosphatase subfamily inhibits insulin signalling by dephosphorylating the insulin receptor at specific sites

R3受容体様蛋白質チロシンホスファターゼサブファミリーは特異部位におけるインスリン受容体脱リン酸によりインスリンシグナル伝達を阻害する

Author (10)： SHINTANI Takafumi (National Inst. for Basic Biology, Okazaki, JPN) ,  SHINTANI Takafumi (Graduate Univ. for Advanced Studies (SOKENDAI), Okazaki, JPN) ,  HIGASHI Satoru (National Inst. for Basic Biology, Okazaki, JPN) ,  HIGASHI Satoru (Graduate Univ. for Advanced Studies (SOKENDAI), Okazaki, JPN) ,  TAKEUCHI Yasushi (National Inst. for Basic Biology, Okazaki, JPN) ,  GAUDIO Eugenio (Univ. Magna Graecia, Catanzaro, ITA) ,  TRAPASSO Francesco (Univ. Magna Graecia, Catanzaro, ITA) ,  FUSCO Alfredo (Universita degli Studi di Napoli Federico II, Napoli, ITA) ,  NODA Masaharu (National Inst. for Basic Biology, Okazaki, JPN) ,  NODA Masaharu (Graduate Univ. for Advanced Studies (SOKENDAI), Okazaki, JPN)
Material： Journal of Biochemistry  (JB)
Volume： 158  Issue： 3  Page： 235-243  Publication year： Sep. 2015 
JST Material Number： W1920A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： HEK293 cell ,...
Semi thesaurus term： cellular signal transduction ,...

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JST classification (2)： Receptors on cell membrane  (EF04030C) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Reference (36)：

• Saltiel, A.R. and Kahn, C.R. (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806
• Bevan, P. (2001) Insulin signaling. J. Cell Sci. 114, 1429-1430
• Drake, P.G. and Posner, B.I. (1998) Insulin receptor-associated protein tyrosine phosphatase(s): role in insulin action. Mol. Cell. Biochem. 182, 79-89
• Goldstein, B.J., Ahmad, F., Ding, W., Li, P.M., and Zhang, W.R. (1998) Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases. Mol. Cell. Biochem. 182, 91-99
• Hashimoto, N., Feener, E.P., Zhang, W.R., and Goldstein, B.J. (1992) Insulin receptor protein-tyrosine phosphatases. Leukocyte common antigen-related phosphatase rapidly deactivates the insulin receptor kinase by preferential dephosphorylation of the receptor regulatory domain. J. Biol. Chem. 15, 13811-13814

Terms in the title (9)： 受容 ,  蛋白質チロシンホスファターゼ ,  サブ ,  ファミリー ,  インスリン受容体 ,  脱リン酸 ,  インスリン ,  シグナル伝達 ,  阻害