Art

J-GLOBAL ID：201502218931555699   Reference number：15A1080367

Novel inhibitors targeting PPM1D phosphatase potently suppress cancer cell proliferation

PPM1Dホスファターゼを標的とする新規阻害剤は癌細胞の増殖を強力に抑制する

Author (8)： OGASAWARA Sari (Lab. of Biological Chemistry, Dep. of Chemistry, Fac. of Sci., Hokkaido Univ., North 10, West 8, Kita-ku, Sapporo ...) ,  KIYOTA Yuhei (Lab. of Biological Chemistry, Dep. of Chemistry, Fac. of Sci., Hokkaido Univ., North 10, West 8, Kita-ku, Sapporo ...) ,  CHUMAN Yoshiro (Lab. of Biological Chemistry, Dep. of Chemistry, Fac. of Sci., Hokkaido Univ., North 10, West 8, Kita-ku, Sapporo ...) ,  KOWATA Ayano (Lab. of Organic Chemistry II, Dep. of Chemistry, Fac. of Sci., Hokkaido Univ., Sapporo 060-0810, JPN) ,  YOSHIMURA Fumihiko (Lab. of Organic Chemistry II, Dep. of Chemistry, Fac. of Sci., Hokkaido Univ., Sapporo 060-0810, JPN) ,  TANINO Keiji (Lab. of Organic Chemistry II, Dep. of Chemistry, Fac. of Sci., Hokkaido Univ., Sapporo 060-0810, JPN) ,  KAMADA Rui (Lab. of Biological Chemistry, Dep. of Chemistry, Fac. of Sci., Hokkaido Univ., North 10, West 8, Kita-ku, Sapporo ...) ,  SAKAGUCHI Kazuyasu (Lab. of Biological Chemistry, Dep. of Chemistry, Fac. of Sci., Hokkaido Univ., North 10, West 8, Kita-ku, Sapporo ...)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 23  Issue： 19  Page： 6246-6249  Publication year： Oct. 01, 2015 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *serine/threonine specific protein phosphatase ,  protein ,  *enzyme inhibitor ,  tumor cell ,  cell proliferation ,  suppression and control ,  p53 protein ,  therapy ,  breast tumor ,  neuroblastoma ,  *inhibition of multiplication ,  induction ,  activity(property) ,  *antitumor drug ,  chemical compound ,  MCF7 cell ,  dephosphorylation ,  phosphatase
Semi thesaurus term： G2/M arrest ,  In vitro activity ,  PPM1D ,  apoptosis induction ,  lead compound ,  Cancer cell ,  anticancer agent ,  anticancer therapy ,  cell propagation depression ,  neuroblastoma ,  inhibitory activity ,  dephosphorylation ,  Breast Cancer ,  target protein

JST classification (4)： Enzyme in general  (EB09010D) ,  Synthesis of drugs  (GV01030F) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (1)： (4aβ,8aα)-3β-(Triethylsiloxy)-5α-(tert-butyldimethylsiloxy)-1-methyldecalin-1α-carboxylic acid

Terms in the title (6)： PPM1D ,  ホスファターゼ ,  標的 ,  阻害剤 ,  癌細胞 ,  増殖