Art

J-GLOBAL ID：201502219804865065   Reference number：15A0954357

Pulmonary administration of phosphoinositide 3-kinase inhibitor is a curative treatment for chronic obstructive pulmonary disease by alveolar regeneration

ホスホイノシチド3-キナーゼ阻害剤の肺投与は肺胞再生により慢性閉塞性肺疾患に対する根治治療になる

Author (5)： HORIGUCHI Michiko (Dep. of Pharmaceutics and Drug Delivery, Fac. of Pharmaceutical Sciences, Tokyo Univ. of Sci., 2641 Yamazaki, Noda ...) ,  OISO Yuki (Dep. of Pharmaceutics and Drug Delivery, Fac. of Pharmaceutical Sciences, Tokyo Univ. of Sci., 2641 Yamazaki, Noda ...) ,  SAKAI Hitomi (Dep. of Pharmaceutics and Drug Delivery, Fac. of Pharmaceutical Sciences, Tokyo Univ. of Sci., 2641 Yamazaki, Noda ...) ,  MOTOMURA Tomoki (Dep. of Pharmaceutics and Drug Delivery, Fac. of Pharmaceutical Sciences, Tokyo Univ. of Sci., 2641 Yamazaki, Noda ...) ,  YAMASHITA Chikamasa (Dep. of Pharmaceutics and Drug Delivery, Fac. of Pharmaceutical Sciences, Tokyo Univ. of Sci., 2641 Yamazaki, Noda ...)
Material： Journal of Controlled Release  (J Control Release)
Volume： 213  Page： 112-119  Publication year： Sep. 10, 2015 
JST Material Number： C0308D  ISSN： 0168-3659  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： phosphatidylinositol 3-kinase ,...
Semi thesaurus term： *Phosphatidylinositol 3-Kinase inhibitor ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=15A0954357&from=J-GLOBAL&jstjournalNo=C0308D") }}

JST classification (4)： Basic biopharmacy  (GY01021U) ,  Basic medicine on respiratory system  (GI01020H) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Cell physiology in general  (EF02010S)

Substance index (2)： Wortmannin ,  AS-605240

Reference (22)：

• K.F. Rabe, S. Hurd, A. Anzueto, PJ. Barnes, S.A. Buist, P. Calverley, Y. Fukuchi, C. Jenkins, R. Rodriguez-Roisin, C. van Weel, J. Zielinski, Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary, Am J. Respir. Crit. Care Med. 176 (2007) 532-555.
• A. Giangreco, E.N. Arwert, I.R. Rosewell, J. Snyder, F.M. Watt, B.R. Stripp, Stem cells are dispensable for lung homeostasis but restore airways after injury, Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 9286-9291.
• J.R Rock, M.W. Onaitis, E.L. Rawlins, Y. Lu, C.P. Clark, Y. Xue, S.H. Randell, B.L. Hogan, Basal cells as stem cells of the mouse trachea and human airway epithelium, Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 12771-12775.
• I.Y. Adamson, D.H. Bowden, The type 2 cell as progenitor of alveolar epithelial regeneration. A cytodynamic study in mice after exposure to oxygen, Lab. Invest. 30 (1974) 35-42.
• MJ. Evans, L.J. Cabral, RJ. Stephens, G. Freeman, Transformation of alveolar type 2 cells to type 1 cells following exposure to NO₂, Exp. Mol. Pathol. 22 (1975) 142-150.

Terms in the title (7)： ホスホイノシチド3-キナーゼ ,  阻害剤 ,  肺 ,  投与 ,  肺胞 ,  慢性閉塞性肺疾患 ,  治療