Art

J-GLOBAL ID：201502226935153546   Reference number：15A0328327

Multitargeting strategy using lenvatinib and golvatinib: Maximizing anti-angiogenesis activity in a preclinical cancer model

レンバチニブとゴルバチニブによる多標的戦略:前臨床腫瘍モデルでの最大化血管新生阻止作用

Author (8)： NAKAZAWA Youya (Tsukuba Res. Lab., Eisai Co., Ltd., Ibaraki, JPN) ,  KAWANO Satoshi ,  MATSUI Junji ,  FUNAHASHI Yasuhiro ,  TOHYAMA Osamu ,  MUTO Hiroki ,  NAKAGAWA Takayuki ,  MATSUSHIMA Tomohiro
Material： Cancer Science (Web)  (Cancer Sci (Web))
Volume： 106  Issue： 2  Page： 201-207  Publication year： Feb. 2015 
JST Material Number： U0505A  ISSN： 1349-7006  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *enzyme inhibitor ,...
Semi thesaurus term： A2780 cell ,...

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JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W)

Substance index (2)： Golvatinib ,  E-7080

Reference (23)：

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• Boss DS, Glen H, Beijnen JH et al. A phase I study of E7080, a multitargeted tyrosine kinase inhibitor, in patients with advanced solid tumours. Br J Cancer 2012; 106: 1598-604.
• Daly C, Pasnikowski E, Burova E et al. Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proc Natl Acad Sci U S A 2006; 103 (42): 15491-6.

Terms in the title (9)： レンバチニブ ,  ゴルバチニブ ,  標的 ,  戦略 ,  臨床 ,  腫瘍 ,  モデル ,  最大化 ,  血管新生阻止作用