Art

J-GLOBAL ID：201502237928284475   Reference number：15A0587509

Dominant negative form of alpha4 inhibits the BCR crosslinking-induced phosphorylation of Bcl-xL and apoptosis in an immature B cell line WEHI-231

alpha4のドミナントネガティブ型は未成熟B細胞株WEHI-231でBCR架橋が誘導したBcl-XLのリン酸化とアポトーシスを阻害する

Author (2)： TANABE Kano (Dep. of Immunology and Hematology, Graduate School of Health Sciences, Fac. of Life Sciences, Kumamoto Univ.) ,  INUI Seiji (Dep. of Immunology and Hematology, Graduate School of Health Sciences, Fac. of Life Sciences, Kumamoto Univ.)
Material： Biomedical Research  (Biomed Res)
Volume： 36  Issue： 2  Page： 97-102 (J-STAGE)  Publication year： 2015 
JST Material Number： Z0236B  ISSN： 0388-6107  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： B cell ,...
Semi thesaurus term： *alpha4 ,...

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JST classification (2)： Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Reference (21)：

• 1 Chen J, Peterson RT and Schreiber SL (1998) Alpha4 associates with protein phosphatase 2A, 4, and 6. Biochem Biophys Res Commun 247, 827-832. 14.
• 2 Davis RJ (2000) Signal transduction by the JNK group of MAP kinases. Cell 103, 239-252.
• 3 Du L, Lyle CS and Chambers TC (2005) Characterization of vinblastine-induced Bcl-xL and Bcl-2 phosphorylation: evidence for a novel protein kinase and a coordinated phosphorylation/dephosphorylation cycle associated with apoptosis induction. Oncogene 24, 107-117.
• 4 Fang W, Rivard JJ, Ganser JA, LeBien TW, Nath KA, Mueller DL and Behrens TW (1995) Bcl-xL rescues WEHI 231 B lymphocytes from oxidant-mediated death following diverse apoptotic stimuli. J Immunol 155, 66-75.
• 5 Healy JI and Goodnow CC (1998) Positive versus negative signaling by lymphocyte antigen receptors. Annu Rev Immunol 16, 645-670.

Terms in the title (9)： ドミナントネガティブ ,  成熟 ,  細胞株 ,  架橋 ,  誘導 ,  Bcl-XL ,  リン酸化 ,  アポトーシス ,  阻害