Art

J-GLOBAL ID：201502250805080499   Reference number：15A0573216

Diallyl trisulfide induces apoptosis in Jurkat cells by the modification of cysteine residues in thioredoxin

ジアリルトリスルフィドはチオレドキシンにおけるシステイン残基の修飾によりJurkat細胞のアポトーシスを誘導する

Author (6)： WATANABE Kazunari (Nihon Univ., Kanagawa, JPN) ,  HOSONO Takashi (Nihon Univ., Kanagawa, JPN) ,  WATANABE Kazuhiro (Nihon Univ., Kanagawa, JPN) ,  HOSONO-FUKAO Tomomi (Ochanomizu Univ., Tokyo, JPN) ,  ARIGA Toyohiko (Nihon Univ., Kanagawa, JPN) ,  SEKI Taiichiro (Nihon Univ., Kanagawa, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 78  Issue： 8  Page： 1418-1420  Publication year： Aug. 2014 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 短報  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *thioredoxin ,...
Semi thesaurus term： cysteine residue ,...

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JST classification (3)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Aliphatic sulfonic acid,sulfinic acid,sulfenic acid and other compounds  (CF03160J) ,  Proteins and peptides in general  (EB03010N)

Substance index (1)： Diallyl pertrisulfide

Reference (11)：

• Herman-Antosiewicz A, Powolny AA, Singh SV. Molecular targets of cancer chemoprevention by garlic-derived organosulfides. Acta. Pharmacol. Sin. 2007;28:1355-1364.
• Na HK, Kim EH, Choi MA, Park JM, Kim DH, Surh YJ. Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1. Biochem. Pharmacol. 2012;84:1241-1250.
• Borkowska A, Sielicka-Dudzin A, Herman-Antosiewicz A, Wozniak M, Fedeli D, Falcioni G, Antosiewicz J. Diallyl trisulfide-induced prostate cancer cell death is associated with Akt/PKB dephosphorylation mediated by P-p66shc. Eur. J. Nutr. 2012;51:817-825.
• Li W, Tian H, Li L, Li S, Yue W, Chen Z, Qi L, Hu W, Zhu Y, Hao B, Gao C, Si L, Gao F. Diallyl trisulfide induces apoptosis and inhibits proliferation of A549 cells in vitro and in vivo. Acta Biochim. Biophys. Sin. 2012;44:577-583.
• Hosono T, Fukao T, Ogihara J, Ito Y, Shiba H, Seki T, Ariga T. Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of β-tubulin. J. Biol. Chem. 2005;280:41487-41493.

Terms in the title (7)： ジアリルトリスルフィド ,  チオレドキシン ,  システイン残基 ,  修飾 ,  Jurkat細胞 ,  アポトーシス ,  誘導