Cardenolide glycosides from the seeds of Digitalis purpurea exhibit carcinoma-specific cytotoxicity toward renal adenocarcinoma and hepatocellular carcinoma cells

FUJINO Tomofumi; KURODA Minpei; MATSUO Yukiko; KUBO Satoshi; TAMURA Chikako; SAKAMOTO Nami; MIMAKI Yoshihiro; HAYAKAWA Makio

Art

J-GLOBAL ID：201502258248969810 Reference number：15A0585644

Cardenolide glycosides from the seeds of Digitalis purpurea exhibit carcinoma-specific cytotoxicity toward renal adenocarcinoma and hepatocellular carcinoma cells

ジギタリスの種子から得られるカルデノリド配糖体による腎臓腺がんおよび肝細胞がんに対する特異的細胞傷害性がん

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Material：
Volume： 79 Issue： 2 Page： 177-184 Publication year： Feb. 2015
JST Material Number： G0021A ISSN： 0916-8451 CODEN： BBBIEJ Document type： Article
Article type：原著論文 Country of issue： United Kingdom (GBR) Language： ENGLISH (EN)

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Carcinogenic mechanisms and factors , Glycosides

Reference (16)：

Kuroda M, Kubo S, Matsuo Y, Atou T, Satoh J, Fujino T, Hayakawa M, Mimaki Y. New cardenolide glycosides from the seeds of Digitalis purpurea and their cytotoxic activity. Biosci. Biotechnol. Biochem. 2013;77:1186-1192.
Zhang Y, Castellani LW, Sinal CJ, Gonzalez FJ, Edwards PA. Peroxisome proliferator-activated receptor-γ coactivator 1 α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR. Genes Dev. 2004;18:157-169.
Fujino T, Takeuchi A, Maruko-Ohtake A, Ohtake Y, Satoh J, Kobayashi T, Tanaka T, Ito H, Sakamaki R, Kashimura R, Ando K, Nishimaki-Mogami T, Ohkubo Y, Kitamura N, Sato R, Kikugawa K, Hayakawa M. Critical role of farnesoid X receptor for hepatocellular carcinoma cell proliferation. J. Biochem. 2012;152:577-586.
Zhang DM, Liu JS, Tang MK, Yiu A, Cao HH, Jiang L, Yuet-Wa Chan JY, Tian HY, Fung KP, Ye WC. Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis. Eur. J. Pharmacol. 2012;692:19-28.
Hwang-Verslues WW, Sladek FM. Nuclear receptor hepatocyte nuclear factor 4α1 competes with oncoprotein c-Myc for control of the p21/WAF1 promoter. Mol. Endocrinol. 2008;22:78-90.

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