Art

J-GLOBAL ID：201502260978595775   Reference number：15A0457489

Identification of anti-HIV agents with a novel benzo[4,5]isothiazolo[2,3-a]pyrimidine scaffold

新規なベンゾ[4,5]イソチアゾロ[2,3-α]ピリミジン足場をもつ抗HIV薬の同定

Author (8)： OKAZAKI Shiho (Graduate School of Pharmaceutical Sciences, Kyoto Univ., Sakyo-ku, Kyoto 606-8501, JPN) ,  MIZUHARA Tsukasa (Graduate School of Pharmaceutical Sciences, Kyoto Univ., Sakyo-ku, Kyoto 606-8501, JPN) ,  SHIMURA Kazuya (Inst. for Virus Res., Kyoto Univ., Sakyo-ku, Kyoto 606-8507, JPN) ,  MURAYAMA Hiroto (Inst. for Virus Res., Kyoto Univ., Sakyo-ku, Kyoto 606-8507, JPN) ,  OHNO Hiroaki (Graduate School of Pharmaceutical Sciences, Kyoto Univ., Sakyo-ku, Kyoto 606-8501, JPN) ,  OISHI Shinya (Graduate School of Pharmaceutical Sciences, Kyoto Univ., Sakyo-ku, Kyoto 606-8501, JPN) ,  MATSUOKA Masao (Inst. for Virus Res., Kyoto Univ., Sakyo-ku, Kyoto 606-8507, JPN) ,  FUJII Nobutaka (Graduate School of Pharmaceutical Sciences, Kyoto Univ., Sakyo-ku, Kyoto 606-8501, JPN)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 23  Issue： 7  Page： 1447-1452  Publication year： Apr. 01, 2015 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *HIV1 ,  HIV infection ,  viral infection ,  *antiviral action ,  *nitrogen heterocyclic compound ,  identification ,  synthesis ,  hydrophobic ,  aryl group ,  displacement (replacement) ,  antiviral drug ,  Structure-Activity Relationship ,  concentration (ratio) ,  effect concentration 50 ,  *Pyrimidines ,  *microorganism ,  *animal virus
Semi thesaurus term： HIV-1 infection ,  *Pyrimidines ,  *anti-HIV-1 activity

JST classification (2)： Basic research of antiviral drugs  (GW17040O) ,  Pyrimidines  (CF07103W)

Substance index (2)： PD-404182 ,  2,3-Dihydro-9-thia-4,9a-diaza-1H-fluorene

Terms in the title (4)： ピリミジン ,  足場 ,  抗HIV薬 ,  同定