Art

J-GLOBAL ID：201502265148422632   Reference number：15A0286640

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

相同組換えのできない腫瘍は,Polθを介した修復に依存している

Author (13)： CECCALDI Raphael (Harvard Medical School, Massachusetts, USA) ,  LIU Jessica C. (Harvard Medical School, Massachusetts, USA) ,  PRIMACK Benjamin (Harvard Medical School, Massachusetts, USA) ,  O'CONNOR Kevin W. (Harvard Medical School, Massachusetts, USA) ,  YUSUFZAI Timur (Harvard Medical School, Massachusetts, USA) ,  D'ANDREA Alan D. (Harvard Medical School, Massachusetts, USA) ,  LIU Jessica C. (Harvard Univ., Massachusetts, USA) ,  AMUNUGAMA Ravindra (Harvard Medical School, Massachusetts, USA) ,  HAJDU Ildiko (Howard Hughes Medical Inst., Massachusetts, USA) ,  ELLEDGE Stephen J. (Howard Hughes Medical Inst., Massachusetts, USA) ,  PETALCORIN Mark I. R. (London Res. Inst., South Mimms, GBR) ,  BOULTON Simon J. (London Res. Inst., South Mimms, GBR) ,  KONSTANTINOPOULOS P. A. (Harvard Medical School, Massachusetts, USA)
Material： Nature (London)  (Nature (Lond))
Volume： 518  Issue： 7538  Page： 258-262  Publication year： Feb. 12, 2015 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *DNA polymerase ,  DNA Repair ,  *ovarian tumor ,  *homologous recombination ,  protein synthesis ,  gene targetting ,  DNA binding protein ,  binding site ,  immunoprecipitation ,  tumor cell ,  cultured cell ,  Cell Cycle ,  U2OS cell ,  pull down assay ,  synthetic lethality ,  protein expression ,  Rad51 Recombinase ,  Gene Knockdown Technique ,  *molecular genetic phenomenon ,  bioassay ,  immunoassay
Semi thesaurus term： *DNAポリメラーゼθ ,  RAD51 ,  マイクロホモロジー依存性末端結合 ,  gene knockdown ,  *epithelial ovarian cancer

JST classification (2)： Molecular genetics in general  (EC02010J) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Terms in the title (3)： 相同組換え ,  腫瘍 ,  修復