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J-GLOBAL ID：201502265833523638   Reference number：15A0334809

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

K13-プロペラ変異はPlasmodium falciparum臨床分離株におけるアルテミシニン耐性を付与する

Author (19)： STRAIMER Judith (Columbia Univ. Coll. Physicians and Surgeons, NY, USA) ,  GNAEDIG Nina F. (Columbia Univ. Coll. Physicians and Surgeons, NY, USA) ,  WITKOWSKI Benoit (Inst. Pasteur du Cambodge, Phnom Penh, KHM) ,  AMARATUNGA Chanaki (National Inst. Health, MD, USA) ,  DURU Valentine (Inst. Pasteur du Cambodge, Phnom Penh, KHM) ,  RAMADANI Arba Pramundita (Lab. Chimie de Coordination, Centre National de la Rech. Scientifique(CNRS), Toulouse, FRA) ,  RAMADANI Arba Pramundita (Univ. Toulouse, Toulouse, FRA) ,  DACHEUX Melanie (Columbia Univ. Coll. Physicians and Surgeons, NY, USA) ,  KHIM Nimol (Inst. Pasteur du Cambodge, Phnom Penh, KHM) ,  ZHANG Lei (Sangamo BioSciences, CA, USA) ,  LAM Stephen (Sangamo BioSciences, CA, USA) ,  GREGORY Philip D. (Sangamo BioSciences, CA, USA) ,  URNOV Fyodor D. (Sangamo BioSciences, CA, USA) ,  MERCEREAU-PUIJALON Odile (Inst. Pasteur, Paris, FRA) ,  BENOIT-VICAL Francoise (Lab. Chimie de Coordination, Centre National de la Rech. Scientifique(CNRS), Toulouse, FRA) ,  BENOIT-VICAL Francoise (Univ. Toulouse, Toulouse, FRA) ,  FAIRHURST Rick M. (National Inst. Health, MD, USA) ,  MENARD Didier (Inst. Pasteur du Cambodge, Phnom Penh, KHM) ,  FIDOCK David A. (Columbia Univ. Coll. Physicians and Surgeons, NY, USA)
Material： Science
Volume： 347  Issue： 6220  Page： 428-431  Publication year： Jan. 23, 2015 
JST Material Number： E0078A  ISSN： 0036-8075  CODEN： SCIEA  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *Plasmodium falciparum ,  antimalarial drug ,  *Drug Resistance ,  mechanism ,  gene locus ,  alicyclic compound ,  lactone ,  bridged compound ,  Genetic Variation ,  drug resistance mechanism ,  *microorganism ,  *protozoa ,  *Sporozoa
Semi thesaurus term： variation(biology) ,  drug resistance mechanism

JST classification (2)： Microorganism physiology in general  (EG03051L) ,  Genetic variation  (EC01030Y)

Substance index (1)： Artemisinin

Terms in the title (6)： プロペラ ,  変異 ,  Plasmodium ,  臨床分離株 ,  アルテミシニン ,  耐性