Art

J-GLOBAL ID：201502273241564300   Reference number：15A0573197

Conformation-specific antibodies to target amyloid β oligomers and their application to immunotherapy for Alzheimer’s disease

アミロイドβオリゴマを標的化する立体配座特異抗体及びAlzheimer病の免疫療法へのこれらの適用

Author (1)： MURAKAMI Kazuma (Kyoto Univ., Kyoto, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 78  Issue： 8  Page： 1293-1305  Publication year： Aug. 2014 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 文献レビュー  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *amyloid beta-protein ,...
Semi thesaurus term： *アミロイドβオリゴマ ,...

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JST classification (3)： Basic neurology  (GN01020W) ,  Proteins and peptides in general  (EB03010N) ,  Antigens,antibodies,complements in general  (ED04010A)

Reference (138)：

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• Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Nat. Acad. Sci. USA. 1985;82:4245-4249.
• Karran E, Mercken M, De Strooper B. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat. Rev. Drug Discovery. 2011;10:698-712.
• Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc. Nat. Acad. Sci. USA. 1986;83:4913-4917.
• Ihara Y, Nukina N, Miura R, Ogawara M. Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease. J. Biochem. 1986;99:1807-1810.

Terms in the title (7)： アミロイドβ ,  オリゴマ ,  標的化 ,  立体配座 ,  特異抗体 ,  Alzheimer病 ,  免疫療法