Art

J-GLOBAL ID：201502278755219930   Reference number：15A0241317

Inhibition of vascular endothelial growth factor receptor under hypoxia causes severe, human-like pulmonary arterial hypertension in mice: Potential roles of interleukin-6 and endothelin

低酸素下における血管内皮成長因子受容体の抑制は,マウスにおいて,重症ヒト様肺高血圧症を引き起こす:インターロイキン-6とエンドセリンの潜在的役割

Author (9)： VAN Hung Tran (Div. of Cardiovascular Medicine, Dep. of Internal Medicine, Kobe Univ. Graduate School of Medicie, Kobe, JPN) ,  EMOTO Noriaki (Div. of Cardiovascular Medicine, Dep. of Internal Medicine, Kobe Univ. Graduate School of Medicie, Kobe, JPN) ,  EMOTO Noriaki (Dep. of Clinical Pharmacy, Kobe Pharmaceutical Univ., Kobe, JPN) ,  VIGNON-ZELLWEGER Nicolas (Dep. of Clinical Pharmacy, Kobe Pharmaceutical Univ., Kobe, JPN) ,  NAKAYAMA Kazuhiko (Div. of Cardiovascular Medicine, Dep. of Internal Medicine, Kobe Univ. Graduate School of Medicie, Kobe, JPN) ,  NAKAYAMA Kazuhiko (Dep. of Clinical Pharmacy, Kobe Pharmaceutical Univ., Kobe, JPN) ,  YAGI Keiko (Dep. of Clinical Pharmacy, Kobe Pharmaceutical Univ., Kobe, JPN) ,  SUZUKI Yoko (Dep. of Clinical Pharmacy, Kobe Pharmaceutical Univ., Kobe, JPN) ,  HIRATA Ken-ichi (Div. of Cardiovascular Medicine, Dep. of Internal Medicine, Kobe Univ. Graduate School of Medicie, Kobe, JPN)
Material： Life Sciences  (Life Sciences including Pharmacology Letters)
Volume： 118  Issue： 2  Page： 313-328  Publication year： Nov. 24, 2014 
JST Material Number： B0699B  ISSN： 0024-3205  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： oxygen deficiency ,  cytokine receptor ,  receptor tyrosine kinase ,  *pulmonary hypertension ,  Mus musculus ,  *interleukin 6 ,  *endothelin ,  action mechanism ,  pathophysiology ,  *development ,  experimental disease ,  angiogenesis inhibitor ,  *Real Time Polymerase Chain Reaction ,  Western blotting ,  immunostaining ,  *histochemistry ,  vascular disease ,  Hypertrophy ,  macrophage ,  vessel wall ,  *polypeptide ,  endothelin A receptor ,  Receptors, Vascular Endothelial Growth Factor ,  *cell signaling ,  *model development ,  Arterial wall ,  *Cell Physiological Phenomena ,  VEGF inhibitor ,  Myomorpha ,  bioassay
Semi thesaurus term： *cell physiology ,  VEGF inhibitor ,  Intimal thickening

JST classification (3)： Basic medicine on respiratory system  (GI01020H) ,  Receptors on cell membrane  (EF04030C) ,  Laboratry organisms  (EA03070Y)

Substance index (2)： SU-5416 ,  Endothelin-1

Terms in the title (10)： 低酸素 ,  血管内皮成長因子 ,  受容体 ,  マウス ,  重症 ,  ヒト ,  肺高血圧症 ,  インターロイキン-6 ,  エンドセリン ,  役割