Art

J-GLOBAL ID：201502279566390110   Reference number：15A0103508

Telmisartan activates endogenous peroxisome proliferator-activated receptor-δ and may have anti-fibrotic effects in human mesangial cells

テルミサルタンは内在性ペルオキシソーム増殖剤活性化受容体-δを活性化し,ヒトメサンギウム細胞において抗線維性作用を持つ可能性がある

Author (9)： MIKAMI Daisuke (Univ. Fukui, Fukui, JPN) ,  KIMURA Hideki (Univ. Fukui, Fukui, JPN) ,  KIMURA Hideki (Univ. Fukui Hospital, Fukui, JPN) ,  KAMIYAMA Kazuko (Univ. Fukui, Fukui, JPN) ,  TORII Kunio (Univ. Fukui Hospital, Fukui, JPN) ,  KASUNO Kenji (Univ. Fukui, Fukui, JPN) ,  TAKAHASHI Naoki (Univ. Fukui, Fukui, JPN) ,  YOSHIDA Haruyoshi (Obama Municipal Hospital, Fukui, JPN) ,  IWANO Masayuki (Univ. Fukui, Fukui, JPN)
Material： Hypertension Research  (Hypertens Res)
Volume： 37  Issue： 5  Page： 422-431  Publication year： May. 2014 
JST Material Number： Y0303A  ISSN： 0916-9636  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *pharmacological action ,...
Semi thesaurus term： TGF-β1 ,...

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JST classification (3)： Basic research of vasoactive drugs and hypotensive drugs  (GW07040J) ,  Kidney  (EJ09030X) ,  Basic medicine on urogenital system  (GM01020T)

Substance index (4)： GSK-0660 ,  2-Chloro-5-nitrobenzanilide ,  GW 0742 ,  Telmisartan

Reference (46)：

• Guan Y, Breyer MD. Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease. Kidney Int 2001; 60: 14-30.
• Barish GD, Narkar VA, Evans RM. PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest 2006; 116: 590-597.
• Neher MD, Weckbach S, Huber-Lang MS, Stahel PF. New insights into the role of peroxisome proliferator-activated receptors in regulating the inflammatory response after tissue injury. PPAR Res 2012; 2012: 728461.
• Stienstra R, Duval C, Muller M, Kersten S. PPARs, obesity, and inflammation. PPAR Res 2007; 2012: 95974.
• Guan Y. Peroxisome proliferator-activated receptor family and its relationship to renal complications of the metabolic syndrome. J Am Soc Nephrol 2004; 15: 2801-2815.

Terms in the title (6)： テルミサルタン ,  ペルオキシソーム増殖剤活性化受容体 ,  活性化 ,  ヒト ,  メサンギウム細胞 ,  可能性