Art

J-GLOBAL ID：201502286274655020   Reference number：15A0287019

Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles

ポリプレックスナノミセルを用いたin vivoでのmRNA導入による神経障害の治療

Author (7)： BABA Miyuki (Lab. of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine ...) ,  BABA Miyuki (Dep. of Otolaryngology, Head and Neck Surgery, Fac. of Medicine, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo ...) ,  ITAKA Keiji (Lab. of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine ...) ,  KONDO Kenji (Dep. of Otolaryngology, Head and Neck Surgery, Fac. of Medicine, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo ...) ,  YAMASOBA Tatsuya (Dep. of Otolaryngology, Head and Neck Surgery, Fac. of Medicine, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo ...) ,  KATAOKA Kazunori (Lab. of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine ...) ,  KATAOKA Kazunori (Dep. of Materials Engineering, Graduate School of Engineering, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo ...)
Material： Journal of Controlled Release  (J Control Release)
Volume： 201  Page： 41-48  Publication year： Mar. 10, 2015 
JST Material Number： C0308D  ISSN： 0168-3659  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： BDNF ,...

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JST classification (1)： Basic biopharmacy  (GY01021U)

Reference (48)：

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• E.N. Hammond, W. Tetzlaff, P. Mestres, K.M. Giehl, BDNF, but not NT-3, promotes long-term survival of axotomized adult rat corticospinal neurons in vivo, Neuroreport 10 (1999) 2671-2675.
• K.M. Giehl, S. Rohrig, H. Bonatz, M. Gutjahr, B. Leiner, I. Bartke, Q. Yan, LF. Reichardt, C. Backus, A.A. Welcher, K. Dethleffsen, P. Mestres, M. Meyer, Endogenous brain-derived neurotrophic factor and neurotrophin-3 antagonistically regulate survival of axotomized corticospinal neurons in vivo, J. Neurosci. 21 (2001) 3492-3502.
• A. Yamamoto, M. Kormann, J. Rosenecker, C. Rudolph, Current prospects for mRNA gene delivery, Eur. J. Pharm. Biopharm. 71 (2009) 484-489.

Terms in the title (3)： mRNA ,  神経障害 ,  治療