Art

J-GLOBAL ID：201502286394544418   Reference number：15A0510036

Acetylation site specificities of lysine deacetylase inhibitors in human cells

ヒト細胞内のリシン脱アセチル化酵素阻害剤のアセチル化部位特異性

Author (16)： SCHOELZ Christian (Univ. Copenhagen, Copenhagen, DNK) ,  WEINERT Brian T (Univ. Copenhagen, Copenhagen, DNK) ,  WAGNER Sebastian A (Univ. Copenhagen, Copenhagen, DNK) ,  BELI Petra (Univ. Copenhagen, Copenhagen, DNK) ,  CHOUDHARY Chunaram (Univ. Copenhagen, Copenhagen, DNK) ,  MIYAKE Yasuyuki (Friedrich Miescher Inst. for Biomedical Res., Basel, CHE) ,  MATTHIAS Patrick (Friedrich Miescher Inst. for Biomedical Res., Basel, CHE) ,  QI Jun (Harvard Medical School, Massachusetts, USA) ,  BRADNER James E (Harvard Medical School, Massachusetts, USA) ,  JENSEN Lars J (Univ. Copenhagen, Copenhagen, DNK) ,  STREICHER Werner (Univ. Copenhagen, Copenhagen, DNK) ,  MCCARTHY Anna R (Karolinska Institutet, Stockholm, SWE) ,  LAIN Sonia (Karolinska Institutet, Stockholm, SWE) ,  WESTWOOD Nicholas J (Univ. St. Andrews, St. Andrews, GBR) ,  COX Juergen (Max Planck Inst. for Biochemistry, Martinsried, DEU) ,  MANN Matthias (Max Planck Inst. for Biochemistry, Martinsried, DEU)
Material： Nature Biotechnology  (Nat Biotechnol)
Volume： 33  Issue： 4  Page： 415-423  Publication year： Apr. 2015 
JST Material Number： H0870A  ISSN： 1087-0156  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： human ,  *enzyme inhibitor ,  *property ,  *Acetylation ,  deacetylation ,  histone ,  *histone deacetylase ,  Proteins ,  *side effect ,  mass spectrometry ,  proteome ,  acetyltransferase ,  transcription factor ,  *amide hydrolase ,  aromatic amine ,  aromatic ketone ,  unsaturated ketone ,  conjugated diene ,  unsaturated carboxylic acid ,  tertiary amine ,  nitrogen heterocyclic compound ,  carboxamide ,  fatty acid ,  phenol ether ,  aliphatic carboxylic acid ,  carboxylate (salt) ,  quantitative mass spectrometry ,  adverse reaction ,  histone deacetylase 6 ,  Hypoxia-Inducible Factor 1, alpha Subunit ,  Sirtuin 1 ,  Histone Acetyltransferases ,  vitamin B family
Semi thesaurus term： HDAC6 ,  HIF-1 alpha ,  SIRT1 protein ,  アセチローム ,  histone acetyltransferase ,  *リシンデアセチラーゼ ,  deacetylation

JST classification (3)： Structure-activity relationship of drugs  (GV01050B) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Enzyme in general  (EB09010D)

Substance index (15)： CI-994 ,  Mocetinostat ,  MS-275 ,  Belinostat ,  SAHA ,  Trichostatin A ,  Apicidin ,  Sirtinol ,  Tubacin ,  Tenovin-6 ,  Niacinamide ,  Valproic acid ,  Pandacostat ,  Bufexamac ,  Butyric acid sodium salt

Terms in the title (6)： ヒト ,  リシン ,  脱アセチル化 ,  酵素阻害剤 ,  アセチル化 ,  部位特異性