Art

J-GLOBAL ID：201502290337974900   Reference number：15A0213417

Retreatment efficacy and safety of tocilizumab in patients with rheumatoid arthritis in recurrence (RESTORE) study

関節リウマチ再発患者におけるトシリズマブ再治療の有効性と安全性(RESTORE)研究

Author (29)： NISHIMOTO Norihiro (Osaka Rheumatology Clinic, Osaka, JPN) ,  NISHIMOTO Norihiro (Tokyo Medical Univ., Tokyo, JPN) ,  NISHIMOTO Norihiro (Wakayama Medical Univ., Wakayama, JPN) ,  AMANO Koichi (Saitama Medical Univ., Saitama, JPN) ,  HIRABAYASHI Yasuhiko (Hikarigaoka Spellman Hospital, Sendai, JPN) ,  HORIUCHI Takahiko (Kyushu Univ. Graduate School of Medical Sci., Fukuoka, JPN) ,  ISHII Tomonori (Tohoku Univ. Graduate School of Medicine, Miyagi, JPN) ,  IWAHASHI Mitsuhiro (Higashihiroshima Memorial Hospital, Higashihiroshima, JPN) ,  IWAMOTO Masahiro (Jichi Medical Univ., Tochigi, JPN) ,  KOHSAKA Hitoshi (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  KONDO Masakazu (Kondo Clinic of Rheumatology and Orthopaedic Surgery, Fukuoka, JPN) ,  MATSUBARA Tsukasa (Matsubara Mayflower Hospital, Hyogo, JPN) ,  MIMURA Toshihide (Saitama Medical Univ., Saitama, JPN) ,  MIYAHARA Hisaaki (Kyushu Medical Center, Fukuoka, JPN) ,  OHTA Shuji (Taga General Hospital, Ibaraki, JPN) ,  SAEKI Yukihiko (Osaka-Minami Medical Center, Osaka, JPN) ,  SAITO Kazuyoshi (Univ. Occupational and Environmental Health Japan, Kitakyushu, JPN) ,  SANO Hajime (Hyogo Coll. Medicine, Hyogo, JPN) ,  TAKASUGI Kiyoshi (Dohgo Spa Hospital, Ehime, JPN) ,  TAKEUCHI Tsutomu (Keio Univ., Tokyo, JPN) ,  TOHMA Shigeto (Sagamihara National Hospital, Kanagawa, JPN) ,  TSURU Tomomi ,  UEKI Yukitaka ,  YAMANA Jiro (Higashihiroshima Memorial Hospital, Higashihiroshima, JPN) ,  HASHIMOTO Jun (Osaka-Minami Medical Center, Osaka, JPN) ,  MATSUTANI Takaji (Wakayama Medical Univ., Wakayama, JPN) ,  MURAKAMI Miho (Tokyo Medical Univ., Tokyo, JPN) ,  MURAKAMI Miho (Wakayama Medical Univ., Wakayama, JPN) ,  TAKAGI Nobuhiro
Material： Modern Rheumatology  (Mod Rheumatol)
Volume： 24  Issue： 1  Page： 26-32  Publication year： 2014 
JST Material Number： L5142A  ISSN： 1439-7595  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： DMARD ,...

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JST classification (2)： Clinical application of anti-inflammatory drugs  (GW15020E) ,  Drug therapy(=pharmacotherapy)for musculoskeletal diseases  (GG05020D)

Reference (20)：

• Choy EH, Isenberg DA, Garrood T, et al. Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin 6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Arthr Rheum. 2002;46:3143-50.
• Nishimoto N, Yoshizaki K, Maeda K, et al. Toxicity, pharmacokinetics, and dose-finding study of repetitive treatment with the humanized anti-interleukin 6 receptor antibody MRA in rheumatoid arthritis. Phase I/II clinical study. J Rheumatol. 2003;30:1426-35.
• Nishimoto N, Yoshizaki K, Miyasaka N, et al. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial. Arthr Rheum. 2004;50:1761-9.
• Maini RN, Taylor PC, Szechinski J, et al. Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthr Rheum. 2006;54:2817-29.
• Nishimoto N, Hashimoto J, Miyasaka N, et al. Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an X-ray reader-blinded randomised controlled trial of tocilizumab. Ann Rheum Dis. 2007;66:1162-7.

Terms in the title (8)： 関節リウマチ ,  再発 ,  患者 ,  トシリズマブ ,  再治療 ,  有効性 ,  安全性 ,  研究