Art

J-GLOBAL ID：201502294950081964   Reference number：15A0560816

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

突然変異の環境は,非小細胞肺癌においてPD-1遮断に対する感受性を決定する

Author (29)： RIZVI Naiyer A. (Memorial Sloan Kettering Cancer Center, NY, USA) ,  RIZVI Naiyer A. (Weill Cornell Medical Coll., NY, USA) ,  HELLMANN Matthew D. (Memorial Sloan Kettering Cancer Center, NY, USA) ,  HELLMANN Matthew D. (Weill Cornell Medical Coll., NY, USA) ,  SNYDER Alexandra (Memorial Sloan Kettering Cancer Center, NY, USA) ,  SNYDER Alexandra (Weill Cornell Medical Coll., NY, USA) ,  KVISTBORG Pia (Netherlands Cancer Inst., Amsterdam, NLD) ,  MAKAROV Vladimir (Memorial Sloan Kettering Cancer Center, NY, USA) ,  HAVEL Jonathan J. (Memorial Sloan Kettering Cancer Center, NY, USA) ,  LEE William (Memorial Sloan Kettering Cancer Center, NY, USA) ,  YUAN Jianda (Memorial Sloan Kettering Cancer Center, NY, USA) ,  WONG Phillip (Memorial Sloan Kettering Cancer Center, NY, USA) ,  HO Teresa S. (Memorial Sloan Kettering Cancer Center, NY, USA) ,  MILLER Martin L. (Memorial Sloan Kettering Cancer Center, NY, USA) ,  REKHTMAN Natasha (Memorial Sloan Kettering Cancer Center, NY, USA) ,  MOREIRA Andre L. (Memorial Sloan Kettering Cancer Center, NY, USA) ,  IBRAHIM Fawzia (Memorial Sloan Kettering Cancer Center, NY, USA) ,  BRUGGEMAN Cameron (Columbia Univ., NY, USA) ,  GASMI Billel (Memorial Sloan Kettering Cancer Center, NY, USA) ,  ZAPPASODI Roberta (Memorial Sloan Kettering Cancer Center, NY, USA) ,  MAEDA Yuka (Memorial Sloan Kettering Cancer Center, NY, USA) ,  SANDER Chris (Memorial Sloan Kettering Cancer Center, NY, USA) ,  GARON Edward B. (UCLA, CA, USA) ,  MERGHOUB Taha (Memorial Sloan Kettering Cancer Center, NY, USA) ,  WOLCHOK Jedd D. (Memorial Sloan Kettering Cancer Center, NY, USA) ,  WOLCHOK Jedd D. (Weill Cornell Medical Coll., NY, USA) ,  SCHUMACHER Ton N. (Netherlands Cancer Inst., Amsterdam, NLD) ,  CHAN Timothy A. (Memorial Sloan Kettering Cancer Center, NY, USA) ,  CHAN Timothy A. (Weill Cornell Medical Coll., NY, USA)
Material： Science
Volume： 348  Issue： 6230  Page： 124-128  Publication year： Apr. 03, 2015 
JST Material Number： E0078A  ISSN： 0036-8075  CODEN： SCIEA  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *Mutation ,  *non-small cell lung cancer ,  *CD antigen ,  *transmembrane protein ,  sensitivity ,  integrity (database) ,  T cell ,  *genetics ,  nucleotide sequence ,  monoclonal antibody ,  molecular targeting drug ,  targeting ,  tumor antigen ,  *Apoptosis ,  survival ratio ,  Prognosis ,  DNA Repair ,  tumor process ,  neoplasm staging ,  chemosensitivity ,  *programmed cell death ,  relapse free survival ,  *Programmed Cell Death 1 Receptor ,  *Genomics ,  genome alignment ,  CD8 positive T cell ,  *natural science
Semi thesaurus term： *PD-1 ,  check point ,  *genome analysis ,  genomic sequence ,  Tumor targeting ,  CD8+ T cell ,  Tumor progression

JST classification (5)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Tumors(=neoplasms)of respiratory system  (GI04000G) ,  Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S) ,  Molecular genetics in general  (EC02010J)

Terms in the title (6)： 突然変異 ,  環境 ,  非小細胞肺癌 ,  PD-1 ,  遮断 ,  感受性