Art

J-GLOBAL ID：201502297155975174   Reference number：15A0296645

Two Novel ALK Mutations Mediate Acquired Resistance to the Next-Generation ALK Inhibitor Alectinib

2つの新規ALK突然変異は次世代ALK阻害剤アレクチニブに対する獲得耐性を媒介する

Author (21)： KATAYAMA Ryohei (Massachusetts General Hospital Cancer Center, Massachusetts) ,  KATAYAMA Ryohei (Harvard Medical School, Massachusetts) ,  KATAYAMA Ryohei (Japanese Foundation for Cancer Res., Tokyo, JPN) ,  FRIBOULET Luc (Massachusetts General Hospital Cancer Center, Massachusetts) ,  FRIBOULET Luc (Harvard Medical School, Massachusetts) ,  KOIKE Sumie (Japanese Foundation for Cancer Res., Tokyo, JPN) ,  LOCKERMAN Elizabeth L. (Massachusetts General Hospital Cancer Center, Massachusetts) ,  LOCKERMAN Elizabeth L. (Harvard Medical School, Massachusetts) ,  KHAN Tahsin M. (Massachusetts General Hospital Cancer Center, Massachusetts) ,  GAINOR Justin F. (Massachusetts General Hospital Cancer Center, Massachusetts) ,  GAINOR Justin F. (Harvard Medical School, Massachusetts) ,  IAFRATE A. John (Massachusetts General Hospital Cancer Center, Massachusetts) ,  IAFRATE A. John (Massachusetts General Hospital, Massachusetts) ,  TAKEUCHI Kengo (Japanese Foundation for Cancer Res., Tokyo, JPN) ,  TAIJI Makoto (Processor Res. Team, RIKEN Advanced Inst. of Computational Sci. 6F, Hyogo, JPN) ,  OKUNO Yasushi (Kyoto Univ., Kyoto, JPN) ,  FUJITA Naoya (Japanese Foundation for Cancer Res., Tokyo, JPN) ,  ENGELMAN Jeffrey A. (Massachusetts General Hospital Cancer Center, Massachusetts) ,  ENGELMAN Jeffrey A. (Harvard Medical School, Massachusetts) ,  SHAW Alice T. (Massachusetts General Hospital Cancer Center, Massachusetts) ,  SHAW Alice T. (Harvard Medical School, Massachusetts)
Material： Clinical Cancer Research  (Clin Cancer Res)
Volume： 20  Issue： 22  Page： 5686-5696  Publication year： Nov. 15, 2014 
JST Material Number： W1296A  ISSN： 1078-0432  Document type： Article
Country of issue： United States (USA)  Language： ENGLISH (EN)

Terms in the title (7)： ALK ,  突然変異 ,  次世代 ,  ALK阻害剤 ,  アレクチニブ ,  獲得 ,  耐性