Art

J-GLOBAL ID：201502298673533327   Reference number：15A0455712

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

TREM2脂質感知はAlzheimer病モデルにおけるミクログリア反応を持続させる

Author (26)： WANG Yaming (Dep. of Pathology and Immunology, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  WANG Yaming (Eli Lilly and Co., Lilly Corporate Center, Indianapolis, IN 46285, USA) ,  CELLA Marina (Dep. of Pathology and Immunology, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  MALLINSON Kaitlin (Dep. of Neurology, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  MALLINSON Kaitlin (Knight Alzheimer’s Disease Res. Center, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  MALLINSON Kaitlin (Hope Center for Neurological Disorders, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  ULRICH Jason D. (Dep. of Neurology, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  ULRICH Jason D. (Knight Alzheimer’s Disease Res. Center, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  ULRICH Jason D. (Hope Center for Neurological Disorders, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  YOUNG Katherine L. (Dep. of Neurology, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  YOUNG Katherine L. (Knight Alzheimer’s Disease Res. Center, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  YOUNG Katherine L. (Hope Center for Neurological Disorders, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  ROBINETTE Michelle L. (Dep. of Pathology and Immunology, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  GILFILLAN Susan (Dep. of Pathology and Immunology, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  KRISHNAN Gokul M. (Dep. of Pathology and Immunology, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  SUDHAKAR Shwetha (Dep. of Neurology, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  SUDHAKAR Shwetha (Knight Alzheimer’s Disease Res. Center, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  SUDHAKAR Shwetha (Hope Center for Neurological Disorders, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  ZINSELMEYER Bernd H. (Dep. of Pathology and Immunology, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  HOLTZMAN David M. (Dep. of Neurology, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  HOLTZMAN David M. (Knight Alzheimer’s Disease Res. Center, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  HOLTZMAN David M. (Hope Center for Neurological Disorders, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  CIRRITO John R. (Dep. of Neurology, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  CIRRITO John R. (Knight Alzheimer’s Disease Res. Center, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  CIRRITO John R. (Hope Center for Neurological Disorders, Washington Univ. School of Medicine, St. Louis, MO 63110, USA) ,  COLONNA Marco (Dep. of Pathology and Immunology, Washington Univ. School of Medicine, St. Louis, MO 63110, USA)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 160  Issue： 6  Page： 1061-1071  Publication year： Mar. 12, 2015 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： amyloid beta-protein ,  *Alzheimer Disease ,  microglia ,  neurophysiology ,  *Membrane Proteins ,  biodistribution ,  cluster formation ,  Apoptosis ,  Cell Membrane ,  membrane lipid ,  experimental disease ,  transgenic mouse ,  knockout mouse ,  gene expression ,  molecular recognition ,  pathophysiology ,  Phagocytosis ,  *Point Mutation ,  *TREM2 ,  Signal Transduction ,  Amyloid ,  glycoprotein ,  animal protein ,  Endomembrane system ,  laboratory animal ,  Mus musculus ,  molecular genetic phenomenon
Semi thesaurus term： cellular signal transduction

JST classification (4)： Basic neurology  (GN01020W) ,  Cell physiology in general  (EF02010S) ,  Central nervous system  (EJ12030F) ,  Biological function  (EB03040U)

Terms in the title (6)： TREM2 ,  脂質 ,  感知 ,  Alzheimer病 ,  モデル ,  ミクログリア