Art

J-GLOBAL ID：201502299949722508   Reference number：15A0367240

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids

がん:CRISPR-Cas9により改変したヒト腸管オルガノイドを用いた大腸がんモデル

Author (11)： MATANO Mami (Keio Univ. School of Medicine, Tokyo, JPN) ,  DATE Shoichi (Keio Univ. School of Medicine, Tokyo, JPN) ,  SHIMOKAWA Mariko (Keio Univ. School of Medicine, Tokyo, JPN) ,  TAKANO Ai (Keio Univ. School of Medicine, Tokyo, JPN) ,  FUJII Masayuki (Keio Univ. School of Medicine, Tokyo, JPN) ,  OHTA Yuki (Keio Univ. School of Medicine, Tokyo, JPN) ,  KANAI Takanori (Keio Univ. School of Medicine, Tokyo, JPN) ,  SATO Toshiro (Keio Univ. School of Medicine, Tokyo, JPN) ,  DATE Shoichi (Otsuka Pharmaceutical Co., Ltd., Shiga, JPN) ,  FUJII Masayuki (Univ. Tokyo, Tokyo, JPN) ,  WATANABE Toshiaki (Univ. Tokyo, Tokyo, JPN)
Material： Nature Medicine  (Nat Med)
Volume： 21  Issue： 3  Page： 256-262  Publication year： Mar. 2015 
JST Material Number： W0636A  ISSN： 1078-8956  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *biomedical tissue ,  *intestine ,  *colorectal neoplasm ,  experimental disease ,  gene expression ,  immunity ,  palindrome ,  caspase ,  gene ,  MAP kinase ,  TGF beta ,  tumor suppressor gene ,  phosphatidylinositol 3-kinase ,  *genetic variation ,  *cellular signal transduction ,  environment ,  *carcinogenesis ,  APC gene ,  ras gene ,  *gene manipulation ,  metastasis ,  cell physiology
Semi thesaurus term： *Organoids ,  CRISPR-Cas Systems ,  Clustered Regularly Interspaced Short Palindromic Repeats ,  Caspase 9 ,  Wnt gene ,  TP53 gene ,  Stem Cell Niche ,  Smad4 gene ,  K-ras gene ,  PIK3CA gene ,  *gene modification ,  Neoplasm Micrometastasis ,  Tumor Microenvironment

JST classification (5)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Tumors(=neoplasms)of digestive system  (GH04000D) ,  Laboratry organisms  (EA03070Y) ,  Gene manipulation  (EC02050B) ,  Cell physiology in general  (EF02010S)

Terms in the title (8)： がん ,  CRISPR-Cas9 ,  改変 ,  ヒト ,  腸管 ,  オルガノイド ,  大腸がん ,  モデル