Rchr
J-GLOBAL ID：201601000520760001
Update date: Jan. 31, 2024
Hamazaki Jun
ハマザキ ジュン | Hamazaki Jun
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Affiliation and department：
The University of Tokyo
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Detailed information
Research field (1)：
Molecular biology
Research keywords (3)：
ユビキチン
, タンパク質分解
, プロテアソーム
Research theme for competitive and other funds (8)：
2022 - 2025 プロテアソーム不全に応答する新たなプロテアソーム機能維持機構の解明
2019 - 2022 Elucidation of a novel homeostatic mechanism by enhanced O-GlcNAcylation under proteasome dysfunction
2016 - 2019 Analysis of the mechanism of the degradation of aggregation prone proteiins by a novel ubiquitin binding protein CG5445
2014 - 2019 Elucidation of redox regulatory mechanisms by transcription factor network
2012 - 2015 Analysis of the mechanism of the regulation of proteasome by novel modifier PI31
2011 - 2013 酸化ストレスにおけるプロテアソームの動態制御機構についての解析
2009 - 2010 酸化ストレスにおけるプロテアソームの動態制御機構についての解析
2009 - 2010 Exploration of novel proteasome modulating proteins by using Drosophila melanogaster
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Papers (35)：
Tomohiro Iriki, Hiroaki Iio, Shu Yasuda, Shun Masuta, Masakazu Kato, Hidetaka Kosako, Shoshiro Hirayama, Akinori Endo, Fumiaki Ohtake, Mako Kamiya, et al. Senescent cells form nuclear foci that contain the 26S proteasome. Cell reports. 2023. 112880-112880
Xiangyu Zhou, Kengo Watanabe, Kazuhiro Morishita, Jun Hamazaki, Shigeo Murata, Isao Naguro, Hidenori Ichijo. Proteasomal regulation of ASK family kinases dictates cell fate under hyperosmotic stress. 2023
Qifang Li, Kiyo-Aki Ishii, Kyoko Kamoshita, Kenta Takahashi, Halimulati Abuduwaili, Hiroaki Takayama, Cynthia M Galicia-Medina, Ryota Tanida, Hein Ko Oo, Guzel Gafiyatullina, et al. PAC1 deficiency protects obese male mice from immobilization-induced muscle atrophy by suppressing FoxO-atrogene axis. Endocrinology. 2023
Nobuo Kanazawa, Hiroaki Hemmi, Noriko Kinjo, Hidenori Ohnishi, Jun Hamazaki, Hiroyuki Mishima, Akira Kinoshita, Tsunehiro Mizushima, Satoru Hamada, Kazuya Hamada, et al. Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency. Nature communications. 2021. 12. 1. 6819-6819
Eiichi Hashimoto, Shota Okuno, Shoshiro Hirayama, Yoshiyuki Arata, Tsuyoshi Goto, Hidetaka Kosako, Jun Hamazaki, Shigeo Murata. Enhanced O-GlcNAcylation Mediates Cytoprotection under Proteasome Impairment by Promoting Proteasome Turnover in Cancer Cells. iScience. 2020. 23. 7. 101299-101299
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MISC (10)：
濱崎 純, 村田 茂穂. Oxidative stress and the regulation of proteasome function. 医学のあゆみ. 2013. 247. 9. 819-824
濱崎 純, 村田 茂穂. 【活性酸素-基礎から病態解明・制御まで】 基礎編 酸化ストレスとプロテアソーム機能制御. 医学のあゆみ. 2013. 247. 9. 819-824
濱崎 純, 村田 茂穂. 【活性酸素・ガス状分子による恒常性制御と疾患 酸化ストレス応答と低酸素センシングの最新知見からがん、免疫、代謝・呼吸・循環異常、神経変性との関わりまで】 (第3章)酸化ストレス・低酸素応答と制御破綻 代謝、タンパク質分解 酸化ストレスとプロテアソーム機能制御. 実験医学. 2012. 30. 17. 2829-2834
荒田 義之, 濱崎 純, 村田 茂穂. 哺乳類新規プロテアソーム会合因子の探索. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010. 83回・33回. 4P-0569
上地 浩之, 濱崎 純, 倉永 英里奈, 三浦 正幸, 村田 茂穂. ショウジョウバエを用いたプロテアソーム遺伝学的相互作用因子の探索. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010. 83回・33回. 4P-0570
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Education (2)：
2005 - 2008 Tokyo Metropolitan University
2003 - 2005 Tokyo Metropolitan University
Professional career (1)：
理学博士 (首都大学東京)
Work history (3)：
2023/05 - 現在 The University of Tokyo Graduate School of Pharmaceutical Sciences Lecturer
2008/09 - 2023/04 The University of Tokyo Graduate School of Pharmaceutical Sciences
2008/04 - 2008/08 東京都臨床医学総合研究所 先端研究センター 日本学術振興会特別研究員PD
Association Membership(s) (1)：
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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