Rchr
J-GLOBAL ID：201601000704238693
Update date: Sep. 23, 2024
Saito Masahiro
サイトウ マサヒロ | Saito Masahiro
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://www.sinai.dent.tohoku.ac.jp/
Research field (1)：
Conservative dentistry and endodontics
Research theme for competitive and other funds (48)：
- 2023 - 2025 歯周組織特異的CAR-MSC細胞を用いた革新的な歯周組織再生移植治療への挑戦
- 2022 - 2025 炎症性腸疾患の疾患活動度をモニターする唾液マーカーの探索
- 2021 - 2024 治療抵抗性口腔疾患に対する革新的抗炎症療法の確立
- 2021 - 2024 Mechanism of undifferentiated maintenance immature osteoblasts under microgravity environment
- 2021 - 2024 類骨オルガノイドを用いた革新的造骨再生医療実用化のための研究基盤構築
- 2020 - 2023 炎症性腸疾患併発下で難治化する根尖性歯周炎の分子病態解析と新規治療標的の検索
- 2020 - 2022 Retrospective quantitative analysis of juvenile stress using dentin matrix
- 2017 - 2022 Development of the new regenerative medicine technique by applying the mechanism of the cytoskeleton reorganization.
- 2018 - 2021 Development of new 3D bone regenerative medicine technology for horizontal bone defects using human ES cells
- 2018 - 2021 Clarification of novel tissue destruction mechanism induced by mechanobiology breakdown
- 2018 - 2020 Molecular mechanisms of p75NTR modulation in the regeneration of pulp sensory function
- 2017 - 2020 Development of high predictive bone regeneration method applying quantitative control mechanism of osteoblast differentiation factor
- 2016 - 2019 Modulation of lipid homeostasis in maintenance and directed differentiation of mesenchymal stem cells
- 2016 - 2019 The development of anti-inflammatory and regenerative medicine for periodontitis: application of Pannexin 3 signaling pathways.
- 2016 - 2018 Development of novel diagnostic technology for marfan syndrome using periodontal tissue
- 2016 - 2018 Development of a method for the endochondral alveolar bone tissue engineering using iPS cells
- 2015 - 2018 Creation of next generation cell therapy for periodontal tissue based on allogenic cell transplantation
- 2014 - 2017 The development of a novel preventive method of periodontal disease using S-PRG Filler eluate
- 2014 - 2017 Regulation and analysis of tooth and salivary gland morphogenesis
- 2014 - 2017 Development of novel therapeutics for the treatment of marfan syndrome using iPS technology
- 2014 - 2017 Regulation and determination of organ derived from invaginated epithelium
- 2014 - 2017 Efficacy and mechanism of Multilineage-differenciating Stress Enduring Cell transplantation in experimental abdominal aortic aneurysm
- 2014 - 2016 Development of novel anti-inflammatory therapy for apical periodontal disease using mesenchymal cell transplantation
- 2012 - 2016 Function and regulation of gap junction on oral epithelium organogenesis
- 2012 - 2015 Elucidate the regulational mechanism of tooth bud formation
- 2011 - 2014 Molecular analysis of inflammasome in periodontal tissue destruction and regeneration.
- 2011 - 2013 Molecular mechanisms of BSP gene transcription on cementblast
- 2011 - 2012 Establishment of screening system for novel therapeutics for periodontal disease by using low molecule compound
- 2009 - 2011 Analysis of regeneration ability of periodontal ligament by ADAMTSL4 and development of novel therapeutic for conservative dentistry
- 2009 - 2010 遺伝子改変マウス作製技術を応用した歯根膜再生モデル動物の開発
- 2008 - 2010 Development of the basic technology for tooth regenerative therapy system
- 2007 - 2009 KK-Periomeデータベースを用いた新規歯周病創薬ターゲットの網羅的探索
- 2007 - 2008 トランスレーショナルリサーチによる歯根膜弾性線維の機能解明への画期的アプローチ
- 2007 - 2008 Transcriptional regulation of BSP gene mediated by cementoblast like cell in vitro
- 2007 - 2008 Possible involvement of sulfation of heparan sulfate proteoglycan in tooth regeneration.
- 2006 - 2007 間葉系細胞移植による新規根管治療技術の開発
- 2006 - 2007 Regeneration of resorbed tooth roots by cementogenesis
- 2005 - 2007 Development of periodontal ligament regeneration therapy using novel extracellular matrix
- 2005 - 2006 シグナル分子を用いた新規象牙質再生医療の開発
- 2004 - 2006 Characterization of Mallase's Epithelial Rest cell line and development to anti-tooth absorbing therapy.
- 2004 - 2005 アメロゲニンの持つ歯根吸収抑制作用の臨床応用にむけて
- 2003 - 2004 歯髄に存在する神経提由来間葉系幹細胞の多能性および可塑性の検討
- 2003 - 2004 Development of poiodontal regenerative medicine that based on molecular mechanism of cementogenesis.
- 2001 - 2002 Establishment of regeneration therapy for periodontium based on the molecular mechanisms of cementogenesis
- 2000 - 2001 Development of Regenerative technologies for Periodontitis based on Human Recombinant Protein Expression System
- 1999 - 2000 歯周組織再生に関する研究:セメント質形成機構の分子生物学的解明
- 1997 - 1998 セメント質中に存在する細胞外マトリックスの菌根膜細胞に対する影響
- 1991 - 1993 Study on The Dentinal Native Non-collagenous Protease
Show all
Papers (91)：
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Takehiro Uematsu, Yoshio Yahata, Koyuki Ohnishi, Shigeto Suzuki, Masafumi Kanehira, Toshinori Tanaka, Susumu Sudo, Venkata Venkataiah Suresh, Masahiro Saito. Irrigation with reduced sodium hypochlorite solution concentration using laser-induced cavitation is effective and safe in rat intraradicular biofilm model. Australian endodontic journal : the journal of the Australian Society of Endodontology Inc. 2023. 49. 3. 544-553
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Tadahiro Yamamoto, Hang Yuan, Shigeki Suzuki, Eiji Nemoto, Masahiro Saito, Satoru Yamada. Procyanidin B2 enhances anti-inflammatory responses of periodontal ligament cells by inhibiting the dominant negative pro-inflammatory isoforms of peroxisome proliferator-activated receptor γ. Journal of Dental Sciences. 2023
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Akiko Sato, Shigeki Suzuki, Hang Yuan, Rahmad Fahreza, Xiuting Wang, Eiji Nemoto, Masahiro Saito, Satoru Yamada. Pharmacological Activation of YAP/TAZ by Targeting LATS1/2 Enhances Periodontal Tissue Regeneration in a Murine Model. International Journal of Molecular Sciences. 2023. 24. 2
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Shigeto Suzuki, Venkata Suresh Venkataiah, Yoshio Yahata, Akira Kitagawa, Masahiko Inagaki, Mary M Njuguna, Risako Nozawa, Yusuke Kakiuchi, Masato Nakano, Keisuke Handa, et al. Correction of large jawbone defect in the mouse using immature osteoblast-like cells and a 3D polylactic acid scaffold. PNAS nexus. 2022. 1. 4. pgac151
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佐藤 瞭子, 鈴木 茂樹, 山本 真豊, 佐々木 健人, 大道寺 美乃, 根本 英二, 齋藤 正寛, 山田 聡. メカノレスポンス受容機構活性化による歯周組織再生. 日本歯周病学会会誌. 2022. 64. 秋季特別. 110-110
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MISC (67)：
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Hang Yuan, Suzuki Shigeki, Sato Akiko, Nemoto Eiji, Saito Masahiro, Shiba Hideki, Yamada Satoru. 歯根膜線維芽細胞の骨/セメント形成能を維持するためには、PPARγによるH3K27全体のアセチル化が必要である(PPARγ-induced global H3K27 acetylation is required to maintain osteo/cementogenic abilities of periodontal ligament fibroblasts). 日本歯周病学会会誌. 2021. 63. 秋季特別. 124-124
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鈴木茂樹, YUAN Hang, 平田(土屋)志津, 根本英二, 齋藤正寛, 柴秀樹, 山田聡. Loss of IκBζ drives tertiary dentin formation via altering H3K4me3 status. 日本歯科保存学会学術大会プログラムおよび講演抄録集(Web). 2021. 155th. 43-43
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Hang Yuan, Suzuki Shigeki, Sato Akiko, Yamamoto Tadahiro, Nemoto Eiji, Saito Masahiro, Yamada Satoru. PPGAγは歯周靱帯細胞の硬部組織形成細胞への分化能の維持にとって必要である(PPARG is required for periodontal ligament cells to retain differentiation capacity of hard-tissue formation). 日本歯周病学会会誌. 2020. 62. 春季特別. 125-125
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佐藤瞭子, 鈴木茂樹, HANG Yuan, 山本真豊, 根本英二, 齋藤正寛, 山田聡. メカノレスポンス因子MAP4K4の歯根膜における発現とその機能解析. 日本歯周病学会会誌(Web). 2020. 62
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Pituitary adenylate cyclase-activating polypeptide promotes eccrine gland sweat secretion. 2018
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Professional career (1)：
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