Research field (5):
Biochemistry
, Bioorganic chemistry
, Structural/physical organic chemistry
, Pharmaceuticals - chemistry and drug development
, Analytical chemistry
Research theme for competitive and other funds (11):
2020 - 2023 miRNAの生細胞内検出を指向した化学反応プローブの開発
2017 - 2021 Development of the nucleic acid sensing probe based on molecule transfer.
2016 - 2018 Development of sophisticated small RNAs utilizing the properties of functional groups
2016 - 2017 人工ヌクレアーゼ分子を用いた遺伝子検出プローブの開発
2016 - 2017 次世代型医療を実現する実用的RNA分子の開発
2015 - 2017 生細胞内での遺伝子検出を指向した分子移動型プローブの開発
2015 - 2017 生細胞内での遺伝子検出を指向した分子移動型プローブの開発
2015 - 2016 特定刺激でRNA干渉効果が誘起されるRNA分子の開発
2015 - 2016 生細胞内での遺伝子検出を指向した分子移動型プローブの開発
2010 - 2011 Development of GST detection probe, and intracellular drug screening
微量遺伝子の検出を指向した自己切断型検出プローブの開発
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Papers (62):
Ayaka Isogami, Sayuri L. Higashi, Bioru Okumura, Aya Shibata, Koichiro M. Hirosawa, Kenichi G. N. Suzuki, Shinya Tsukiji, Kazunori Matsuura, Masato Ikeda. Hierarchical supramolecular structure comprising reduction-responsive DNA microspheres and semi-artificial glycopeptide-based micro-asters. Polymer Journal. 2023
Shintaro Sugiura, Yuki Shintani, Sayuri L. Higashi, Aya Shibata, Masato Ikeda. Dihydrolevoglucosenone (Cyrene) as a bio-based green alternative to organic solvents for the preparation of supramolecular gels consisting of self-assembling dipeptide derivatives. 2023
Sayuri L. Higashi, Ayaka Isogami, Junko Takahashi, Aya Shibata, Koichiro M. Hirosawa, Kenichi G.N. Suzuki, Shunsuke Sawada, Shinya Tsukiji, Kazunori Matsuura, Masato Ikeda. Construction of a Reduction-responsive DNA Microsphere using a Reduction-cleavable Spacer based on a Nitrobenzene Scaffold. Chemistry - An Asian Journal. 2022
Aya Shibata, Sayuri L. Higashi, Masato Ikeda. Nucleic acid-based fluorescent sensor systems: a review. Polymer Journal. 2022
Yuki Shintani, Taku Ohtomi, Aya Shibata, Yoshiaki Kitamura, Koichiro M. Hirosawa, Kenichi G. N. Suzuki, Masato Ikeda. Formation of Supramolecular Nanostructures through in Situ Self-Assembly and Post-Assembly Modification of a Biocatalytically Constructed Dipeptide Hydrazide**. Chemistry - A European Journal. 2022. 28. 8