Itoh Ari

Affiliation and department：

Research field (1)： Immunology

Research theme for competitive and other funds (5)：

2022 - 2025 急性骨髄性白血病治療に特化したCXCR4発現CD25標的キメラT細胞の解析
2019 - 2022 Functional elucidation of transcription factor Bach2 in the development and maintenance of acute myeloid leukemia
2017 - 2019 Elucidation of the acquisition mechanism of a long life in plasma cells
2015 - 2017 A Bach2-Cebp gene regulatory network for the commitment of multipotent hematopoietic progenitors
2015 - 2017 Regulation of lineage fate in hematopoietic stem cells by Bach2(Fostering Joint International Research)

Papers (46)：

Mei-Tzu Su, Masanori Inui, Yi Li Wong, Maika Takahashi, Akiko Sugahara-Tobinai, Karin Ono, Shotaro Miyamoto, Keiichi Murakami, Ari Itoh-Nakadai, Dai Kezuka, et al. Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice. International immunology. 2021. 33. 8. 447-458
Kato H, Itoh-Nakadai A, Matsumoto M, Ishii Y, Watanabe-Matsui M, Ikeda M, Ebina-Shibuya R, Sato Y, Kobayashi M, Nishizawa H, et al. Infection perturbs Bach2- and Bach1-dependent erythroid lineage 'choice' to cause anemia. Nature immunology. 2018. 19. 10. 1059-1070
Kayaba A, Itoh-Nakadai A, Niibe K, Shirota M, Funayama R, Sugahara-Tobinai A, Wong YL, Inui M, Nakayama K, Takai T. Bone marrow PDGFRα+Sca-1+-enriched mesenchymal stem cells support survival of and antibody production by plasma cells in vitro through IL-6. International immunology. 2018. 30. 6. 241-253
Miura Y, Morooka M, Sax N, Roychoudhuri R, Itoh-Nakadai A, Brydun A, Funayama R, Nakayama K, Satomi S, Matsumoto M, et al. Bach2 Promotes B Cell Receptor-Induced Proliferation of B Lymphocytes and Represses Cyclin-Dependent Kinase Inhibitors. Journal of immunology (Baltimore, Md. : 1950). 2018. 200. 8. 2882-2893
Ari Itoh-Nakadai, Atsuko Kayaba, Toshiyuki Takai. Secretory leukocyte peptidase inhibitor (SLPI) is highly expressed in long-lived plasma cells. CYTOKINE. 2017. 100. 166-166

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MISC (18)：

稲垣弘文, 平田幸代, 清水孝子, 小林麻衣子, 伊藤亜里, 川田智之. Effect of IL-2 on the production of granzyme 3 in KHYG-1 cells. 日本薬学会年会要旨集(Web). 2023. 143rd
稲垣弘文, 伊藤亜里, 平田幸代, 清水孝子, 小林麻衣子, 川田智之. KHYG-1細胞のグランザイム産生のFlow Cytometryによる解析. 日本生化学会大会(Web). 2023. 96th
Ari Itoh-Nakadai, Yoriko Saito, Mariko Murasawa-Tomizawa, Hiroshi Kajita, Takehisa Matsumoto, Masashi Matsuda, Takashi Watanabe, Mikako Shirouzu, Osamu Ohara, Haruhiko Koseki, et al. CXCR4-Expressing Anti-CD25 CAR T-Cells Effectively Eliminate Human AML Cells In Vivo. Blood. 2020. 136. Supplement 1. 35-36
Hiroki Kato, Ari Itoh-Nakadai, Mitsuyo Matsumoto, Risa Ebina-Shibuya, Yuki Sato, Masahiro Kobayashi, Akihiko Muto, Tohru Fujiwara, Hideo Harigae, Kazuhiko Igarashi. Transcription Factor Bach1 and Bach2 Operate Erythro-Myeloid Competitive Differentiation By Responding to Environmental Changes. BLOOD. 2016. 128. 22
Koichi Onodera, Tohru Fujiwara, Yasushi Onishi, Ari Itoh-Nakadai, Yoko Okitsu, Noriko Fukuhara, Kenichi Ishizawa, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae. GATA-2 Regulates Dendritic Cell Differentiation. BLOOD. 2015. 126. 23

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Lectures and oral presentations (5)：

Targeting poor prognosis acute myeloid leukemia with CD25-targeted chemokine receptor expressing CAR T cell therapy
(2024)
Elucidating Tissue-Specific Metabolisms in Chimeric Antigen Receptor T-Cell Therapy
(The 52nd Annual Meeting of the Japanese Society for Immunology 2024)
Targeting poor prognosis acute myeloid leukemia with CD25-targeted chemokine receptor expressing CAR T cell therapy
(The 51st Annual Meeting of the Japanese Society for Immunology 2022)
Targeting poor prognosis leukemia with CD25-targeted chemokine receptor expressing CAR-T cell therapy
(2022)
CXCR4-Expressing Anti-CD25 CAR T-Cells Effectively Eliminate Human AML Cells In Vivo
(Blood 2020)

Professional career (1)：

Awards (6)：

2021/12 - Best presentation award Targeting poor prognosis leukemia with CD25-targeted chemokine receptor expressing CAR Tcell therapy
2019/12 - The Japanese Society for Immunology Best Presentation Award Creation of HLA class I and class II Tg NOD/SCID/Il2rgKO (NSG) mice for studying interaction between human immunity and leukemia
2015/12 - The Japanese Society for Immunology Best Presentation Award Bach2 represses myeloid programs to promote lymphoid progenitor development under both the steady state and infection
2015/10 - International Immunological Memory and Vaccine Forum (IIMVF) Travel award for Young Scientists -
2015/03 - The Elkes foundation Keystone Symposia Future of science fund, National institution of allergy and infection diseases (NIAID) -

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