Ninagawa Satoshi

Affiliation and department：
Job title： Assistant Professor
Other affiliations (1)：

Kobe University Graduate School of Agricultural Science Department of Bioresource Science Assistant Professor

Homepage URL (1)： http://www2.kobe-u.ac.jp/~ninagawa/

Research field (3)： Zoological sciences , Applied molecular and cellular biology , Cell biology

Research keywords (4)： Protein quality control , mannose trimming , EDEM , ER associated degradation

Research theme for competitive and other funds (10)：

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Papers (26)：

Young-Ho Lee, Tomohide Saio, Mai Watabe, Motonori Matsusaki, Shingo Kanemura, Yuxi Lin, Taro Mannen, Tsubura Kuramochi, Katsuya Iuchi, Michiko Tajiri, et al. Ca²⁺-driven PDIA6 phase separation to ensure proinsulin quality control. 2024
Satoshi Ninagawa, Masaki Matsuo, Deng Ying, Shinya Aso, Kazutoshi Matsushita, Akane Fueki, Shunsuke Saito, Koshi Imami, Yasuhiko Kizuka, Tetsushi Sakuma, et al. UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins. 2023
Tomoyo Ikeda, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Masaya Ono, Kazutoshi Mori. Proteomic analysis of fatty liver induced by starvation of medaka fish larvae. Cell structure and function. 2023. 48. 2. 123-133
Shengyu Jin, Byungseok Jin, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Sho Koyasu, Hiroshi Harada, Kazutoshi Mori. Loss of ATF6α in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6β but by Sustained Activation of the IRE1 and PERK Arms for Tumor Growth in Nude Mice. Molecular Biology of the Cell. 2023
Shunsuke Saito, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Kazutoshi Mori. A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis by inactivating SERCA2b. eLife. 2022. 11

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MISC (4)：

蜷川暁. 小胞体におけるN型糖鎖による糖タンパク質の品質管理機構. Trends in glycoscience and glycotechnology. 2021. 33. 191-193. J55-62
蜷川暁. N-glycan Dependent Protein Quality Control System in the Endoplasmic Reticulum. Trends in Glycoscience and Glycotechnology (Web). 2021. 33. 193. E55-E62
蜷川暁. Molecular mechanism of protein folding and degradation machinery in the mammalian endoplasmic reticulum. 生化学. 2021. 93. 4
蜷川暁, GEORGE Ginto, 矢木宏和, 住友嘉樹, 石川時郎, 佐久間哲史, 山本卓, 今見考志, 石濱泰, 加藤晃一, et al. 小胞体関連分解因子EDEM2は,TXNDC11とジスルフィド結合を介した複合体を形成し,マンノシダーゼ活性を発揮する. 日本生化学会大会(Web). 2020. 93rd. [2Z01-027)]

Lectures and oral presentations (35)：

Folding or Degradation, Molecular Mechanisms Determining the Fate of Glycoproteins in the Endoplasmic Reticulum
(日本分子生物学会年会プログラム・要旨集(Web) 2023)
Functional analysis of Golgi-localized mannosidase MAN1B1.
(日本分子生物学会年会プログラム・要旨集(Web) 2023)
小胞体における構造不全糖タンパク質の代謝タイミング決定の分子機構
(日本生化学会大会(Web) 2023)
UGGTs prevent premature degradation of unstable and misfolded glycoproteins in the endoplasmic reticulum
(日本糖質学会年会要旨集 2023)
Effects of the endoplasmic reticulum folding sensor UGGT on secretion
(日本分子生物学会年会プログラム・要旨集(Web) 2023)

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Education (4)：

Work history (5)：

2021/10 - 現在 Graduate School of Agricultural Sciences, Kobe University Department of Applied Chemistry in Bioscience Assistant Professor
2021/10 - 現在 Kobe University Biosignal Research Center
2015/07 - 2021/09 京都大学大学院理学研究科
2014/04 - 2015/06 自然科学研究機構岡崎統合バイオサイエンスセンター
2005/04 - 2014/03 -

Awards (6)：

2023/04 - 長瀬研究振興賞
2020 - 日本糖質学会日本糖質学会奨励賞高等動物におけるN 型糖鎖のマンノース切除を基軸とした小胞体関連分解機構の解析
2020 - 日本生化学会日本生化学会奨励賞遺伝子破壊法を用いた小胞体関連分解機構の解明
2017 - CSF award SEL1L-dependent Substrates Require Derlin2/3 and Herp1/2 for Endoplasmic Reticulum-associated Degradation
2016/06 - 日本細胞生物学会若手優秀発表賞分解執行局域における新展開

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Association Membership(s) (4)：

日本糖質学会 , 日本細胞生物学会 , 日本分子生物学会 , 日本生化学会

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