Yuki Nakaya

ナカヤユウキ | Yuki Nakaya

Affiliation and department：

Research field (3)： Virology , Molecular biology , Veterinary medicine

Research keywords (2)： Hepatitis virus , Endogenous retrovirus

Research theme for competitive and other funds (11)：

2024 - 2029 PreS2領域にHiBiTタグを有するB型肝炎ウイルスレポーターを用いた新規HBs抗原放出阻害剤の探索
2024 - 2027 cccDNA排除を目的とした新規レポーターウイルスによるHBs抗原放出阻害剤の探索
2022 - 2025 免疫賦活およびウイルス宿主免疫抑制機構の抑制によるB型肝炎治療の開発
2022 - 2025 Nucleotide analog製剤の宿主免疫賦活能を利用してB型肝炎のHBs抗原消失率向上を目指す治療法の開発および創薬に関する研究
2021 - 2024 Molecular function of RNA binding protein of endogenous retroviruses

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Papers (26)：

Yuki Nakaya, Daichi Onomura, Yuji Hoshi, Tomoko Yamagata, Hiromi Morita, Hiroaki Okamoto, Kazumoto Murata. Establishment of a hepatitis B virus reporter system harboring a HiBiT-tag in the PreS2 region. The Journal of Infectious Diseases. 2024
Ryogo Shimizu, Kazuhisa Murai, Kensuke Tanaka, Yuga Sato, Naho Takeda, Saki Nakasyo, Takayoshi Shirasaki, Kazunori Kawaguchi, Tetsuro Shimakami, Kouki Nio, et al. Nucleos(t)ide analogs for hepatitis B virus infection differentially regulate the growth factor signaling in hepatocytes. Hepatology Communications. 2024. 8. 1
Yuki Nakaya, Tsutomu Nishizawa, Hironori Nishitsuji, Hiromi Morita, Tomoko Yamagata, Daichi Onomura, Kazumoto Murata. TRIM26 positively affects hepatitis B virus replication by inhibiting proteasome-dependent degradation of viral core protein. Scientific Reports. 2023. 13. 1. 13584
Masato Yasuura, Yuki Nakaya, Hiroki Ashiba, Takashi Fukuda. Investigation on the applicability of a long-range reverse-transcription quantitative polymerase chain reaction assay for the rapid detection of active viruses. BMC Microbiology. 2022. 22. 1. 300
Yuki Nakaya, Takashi Fukuda, Hiroki Ashiba, Masato Yasuura, Makoto Fujimaki. Quick assessment of influenza a virus infectivity with a long-range reverse-transcription quantitative polymerase chain reaction assay. BMC INFECTIOUS DISEASES. 2020. 20. 1. 585

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MISC (34)：

Nakaya Yuki, Murata Kazumoto. TRIM26 helps HBV replication by inhibiting proteasome-dependent degradation of HBV core protein. 2023. 64. Suppl.2. A530-A530
仲屋友喜, 本多政夫, 村田一素. 肝細胞特異的に高発現する内在性レトロウイルス由来因子の肝癌抑制機能. 肝臓. 2023. 64. Suppl.1. A398-A398
仲屋友喜, 村田一素. 宿主免疫逃避機構の抑制による抗HBV効果の解析. 肝臓. 2022. 63. Suppl.2. A604-A604
仲屋友喜, 福田隆史, 芦葉裕樹, 安浦雅人, 藤巻真. 紫外線ランプによるインフルエンザウイルス殺菌効果の迅速評価手法-Examination of the sterilization effect of UV irradiation on influenza virus infectivity without cell culture-光・量子デバイス研究会・パワー光源システム技術. 電気学会研究会資料. OQD = The papers of technical meeting on optical and quantum devices, IEE Japan / 光・量子デバイス研究会 [編]. 2020. 2020. 41-45. 25-28
Detection of Influenza Virus Using External Force-Assisted Near-Field Illumination (EFA-NI) Biosensor. 2018. 35. 4p

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Patents (2)：

Lectures and oral presentations (2)：

TRIM26 supports HBV replication by protecting core protein from proteasome-dependent degradation
(10th Korea-Japan-Taiwan HBV RESEARCH SYMPOSIUM 2024)
HEPATITIS B VIRUS HIJACK HOST TRIM26 TO AVOID PROTEASOME-DEPENDENT DEGRADATION OF VIRAL CORE PROTEIN
(The Liver Meeting® 2023 2023)

Education (2)：

Professional career (2)：

Work history (10)：

2022/10 - 現在 Jichi Medical University
2021/04 - 2022/09 Jichi Medical University
2019/04 - 2021/03 National Institute of Advanced Industrial Science and Technology (A)ST) Sensing system research center Senior Researcher
2017/10 - 2019/03 National Institute of Advanced Industrial Science and Technology Optical Sensing Group Postdoc
2017/04 - 2017/09 富山県農林水産総合技術センター畜産研究所養豚課研究員(獣医師採用)

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Awards (8)：

2024/11 - 公益財団法人武田科学振興財団 2024年度武田科学振興財団医学系研究助成(感染領域) PreS2領域にHiBiTタグを有するB型肝炎ウイルスレポーターを用いた新規HBs抗原放出阻害剤の探索
2022/10 - Organization of Japan Digestive Disease Week Outstanding Poster Award Investigation of the anti-HBV effect by suppressing an immune evasion machinery of HBV
2022/04 - 公益財団法人ウイルス肝炎研究財団肝炎に関する研究助成事業(研究奨励金) HBV根治療法の開発に向けたHBVと宿主因子の相互作用の解明
2013/04 - Japan Society for the Promotion of Science (JSPS) Research Fellowship for Young Scientists (SPD)
2011/10 - World Congress of Reproductive Biology Centre for Reproductive Genomics Poster Award

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