Research keywords (4)：
ケミカルバイオロジー
, 細胞周期
, 転写
, スプライシング
Research theme for competitive and other funds (9)：
2023 - 2025 プロテアソームによる異常タンパク質分解を活性化して健康寿命を伸ばす
2021 - 2024 スプライシング異常細胞を排除する「細胞の品質管理機構」の解明
2020 - 2023 神経系におけるトランスクリプトーム品質管理機能と関連疾患の解明
2020 - 2022 Development of anti-Alzheimer's disease based on a ubiquitin-proteasome activator
2013 - 2017 Study on the splicing checkpoint mechanism to prevent pre-mRNA accumulation caused by splicing abnormality
2014 - 2016 Study on regulation of addipocyte differentiation through the control of mRNA splicing activity
2012 - 2014 Study on the mechanism of tissue specific diseases caused by mRNA splicing defect
2011 - 2013 遺伝情報の正確性を保つスプライシングチェックポイント機構の解析
2006 - 2007 mRNA遺伝情報の正確性に関する化学生物学的研究
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Papers (29)：
Yuta Inagaki, Kohki Hashimoto, Shinnosuke Wakamori, Ryo Katsuta, Arata Yajima, Daisuke Kaida, Ken Ishigami. Synthesis, growth inhibitory activity against tumor cells, and structure-activity relationship of CGK733 and its analogs. Bioscience, biotechnology, and biochemistry. 2024. 88. 7. 747-758
Mohamed Darwish, Masatoshi Ito, Yoko Iijima, Akinori Takase, Noriko Ayukawa, Satoko Suzuki, Masami Tanaka, Kanae Komori, Daisuke Kaida, Takatoshi Iijima. Neuronal SAM68 differentially regulates alternative last exon splicing and ensures proper synapse development and function. The Journal of biological chemistry. 2023. 299. 10. 105168-105168
Daisuke Kaida, Takayuki Satoh, Ken Ishida, Rei Yoshimoto, Kanae Komori. A Truncated Form of the p27 Cyclin-Dependent Kinase Inhibitor Translated from Pre-mRNA Causes G2-Phase Arrest. Molecular and cellular biology. 2022. e0021722
Daisuke Kaida, Kenta Shida. Spliceostatin A stabilizes CDKN1B mRNA through the 3' UTR. Biochemical and biophysical research communications. 2022. 608. 39-44
Daisuke Kaida, Takayuki Satoh, Ken Ishida, Rei Yoshimoto. A truncated form of the p27 CDK inhibitor translated from pre-mRNA causes cell cycle arrest at G2 phase. bioRxiv. 2022
Mitsunori Koga, Takayuki Satoh, Daisuke Kaida. U2 snRNP is required for the phosphorylation of Pol II CTD Ser2 and efficient transcription elongation. FASEB JOURNAL. 2014. 28. 1
1994 - 1998 The University of Tokyo Faculty of Science Department of Biological Sciences
Work history (5)：
2016/04 - 現在 University of Toyama
2015/04 - 2016/03 University of Toyama
2011/03 - 2015/03 University of Toyama
2007/10 - 2011/02 ペンシルベニア大学 医学部 ポスドク
2003/04 - 2007/09 理化学研究所 吉田化学遺伝学研究室 ポスドク
Awards (1)：
2014/04 - 文部科学省 科学技術分野の文部科学大臣表彰 若手科学者賞
Association Membership(s) (6)：
The RNA society
, JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
, THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER
, THE JAPANESE CANCER ASSOCIATION
, THE RNA SOCIETY OF JAPAN
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
