DAISUKE HOSHINO

ホシノダイスケ | DAISUKE HOSHINO

Affiliation and department：

Research field (1)： Tumor biology

Research keywords (7)：浸潤突起 , プロテアーゼ , イメージング , 細胞運動 , エクソソーム , 浸潤転移 , がん

Research theme for competitive and other funds (17)：

2024 - 2026 甲状腺癌オルガノイドを用いた放射性ヨウ素治療抵抗性機序の解明
2023 - 2026 Development of benign/malignant differentiation method for thyroid follicular tumor using organoids
2023 - 2026 甲状腺癌オルガノイドを用いた放射性ヨウ素治療抵抗性機序の解明
2023 - 2026 Investigation of the suppression mechanism of bone marrow adipocyte-derived adiponectin on bone metastatic cancer
2021 - 2024 腫瘍内不均一性を反映したシングルセルオルガノイド培養系の構築と薬剤耐性機構の解明

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Papers (39)：

Hirotaka Nakayama, Nao Saito, Rika Kasajima, Nobuyasu Suganuma, Yasushi Rino, Katsuhiko Masudo, Haruhiko Yamazaki, Soji Toda, Kazumasa Sekihara, Hiroyuki Iwasaki, et al. Validation of EZH2 Inhibitor Efficiency in Anaplastic Thyroid Carcinoma Cell Lines. Anticancer research. 2023. 43. 3. 1073-1077
Kazumasa Sekihara, Hidetomo Himuro, Nao Saito, Yukihide Ota, Taku Kouro, Yohsuke Kusano, Shinichi Minohara, Ryoichi Hirayama, Hiroyuki Katoh, Tetsuro Sasada, et al. Evaluation of X-ray and carbon-ion beam irradiation with chemotherapy for the treatment of cervical adenocarcinoma cells in 2D and 3D cultures. Cancer cell international. 2022. 22. 1. 391-391
Shinya Sato, Satoshi Maki, Takashi Yamanaka, Daisuke Hoshino, Yukihide Ota, Emi Yoshioka, Kae Kawachi, Kota Washimi, Masaki Suzuki, Yoichiro Ohkubo, et al. Machine learning-based image analysis for accelerating the diagnosis of complicated preneoplastic and neoplastic ductal lesions in breast biopsy tissues. Breast cancer research and treatment. 2021. 188. 3. 649-659
Makoto Nagano, Daisuke Hoshino, Jiro Toshima, Motoharu Seiki, Naohiko Koshikawa. NH2 -terminal fragment of ZF21 protein suppresses tumor invasion via inhibiting the interaction of ZF21 with FAK. Cancer science. 2020. 111. 12. 4393-4404
Tatsuya Yoshida, Nobuyasu Suganuma, Shinya Sato, Soji Toda, Hirotaka Nakayama, Katsuhiko Masudo, Yoichiro Okubo, Hiroyuki Hayashi, Tomoyuki Yokose, Naohiko Koshikawa, et al. Membrane type 1 matrix metalloproteinase regulates anaplastic thyroid carcinoma cell growth and invasion into the collagen matrix. Biochemical and biophysical research communications. 2020. 529. 4. 1195-1200

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MISC (3)：

関原和正, 氷室秀知, 齋藤菜緒, 太田幸秀, 笹田哲朗, 星野大輔. 子宮頸部腺がん三次元スフェロイドにおける炭素線照射の抗腫瘍効果(The antitumor effect of carbon ion irradiation in three-dimensional spheroids from cervical adenocarcinoma.). 日本癌学会総会記事. 2022. 81回. P-1354
D. Hoshino, J. Jourquin, W. Emmons, T. Miller, M. Goldgof, K. Costello, D. Tyson, B. Brown, Y. Lu, N. Prasad, et al. Network analysis of the focal adhesion-invadopodia transition identifies a PI 3-kinase-PKCalpha invasive signaling axis. MOLECULAR BIOLOGY OF THE CELL. 2012. 23
D Hoshino, A Hayashi, N Kanzawa, T Tsuchiya. Biochemical characterization of annexin from Mimosa pudaica. PLANT AND CELL PHYSIOLOGY. 2003. 44. S37-S37

Professional career (1)：

医学博士 (東京大学)

Work history (5)：

2014/08 - 現在 Kanagawa Cancer Center, Research Institute
2012/09 - 2014/07 Vanderblit 大学医学センター Weaver Lab ポスドク
2009/09 - 2012/08 The University of Tokyo The Institute of Medical Science, Division of Cancer Cell Research
2008/04 - 2009/08 The University of Tokyo The Institute of Medical Science, Division of Cancer Cell Research
2005/04 - 2008/03 日本学術振興会特別研究員 DC1

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