Jun Aono

Affiliation and department：

Research field (2)： Pathobiochemistry , Internal medicine - General

Research theme for competitive and other funds (9)：

2022 - 2026 Understanding the molecular mechanism of aortic valve calcification at the single-cell level
2022 - 2026 単一細胞レベルでの大動脈弁石灰化機構の統合的理解
2020 - 2023 リソソーム機能異常による心不全発症機構の解明
2017 - 2023 肥大型心筋症の心不全発症メカニズム-トランスクリプトーム網羅解析からの検討-
2018 - 2021 ヒト臨床検体を用いた大動脈弁狭窄症の分子機序・血中病態予測マーカーの探索

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Papers (71)：

Munenori Komoda, Tomohisa Sakaue, Yasuhisa Nakao, Hiroshi Sakamoto, Takuma Fukunishi, Tomohide Higaki, Jun Aono, Hirotsugu Kurobe, Mie Kurata, Takashi Nishimura, et al. Caldesmon-1-mediated actin dynamics is essential for osteogenic differentiation of aortic valve interstitial cells. Scientific reports. 2026
Yasuhisa Nakao, Jun Aono, Mika Hamaguchi, Kayo Takahashi, Tomohisa Sakaue, Katsuji Inoue, Shuntaro Ikeda, Osamu Yamaguchi. Author Correction: O-ring-induced transverse aortic constriction (OTAC) is a new simple method to develop cardiac hypertrophy and heart failure in mice. Scientific reports. 2025. 15. 1. 12964-12964
Tomohisa Sakaue, Tadaaki Koyama, Yoshitsugu Nakamura, Keitaro Okamoto, Takayuki Kawashima, Tadashi Umeno, Yasuhide Nakayama, Shinji Miyamoto, Fumiaki Shikata, Mika Hamaguchi, et al. Bioprosthetic Valve Deterioration: Accumulation of Circulating Proteins and Macrophages in the Valve Interstitium. JACC. Basic to translational science. 2023. 8. 7. 862-880
七條聖, 莖田昌敬, 牧田愛祐, 青野潤, 三好賢一, 山口修. LPSの腹腔内投与による腹膜線維化モデルマウスの樹立. 日本腎臓学会誌. 2023. 65. 3. 264-264
Kayo Takahashi, Jun Aono, Yasuhisa Nakao, Mika Hamaguchi, Chika Suehiro, Mie Kurata, Tomohisa Sakaue, Akemi Kakino, Tatsuya Sawamura, Katsuji Inoue, et al. LOX-1 deficiency increases ruptured abdominal aortic aneurysm via thinning of adventitial collagen. Hypertension research : official journal of the Japanese Society of Hypertension. 2022. 46. 1. 63-74

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MISC (351)：

薦田宗則, 坂上倫久, 坂上倫久, 濱口美香, 坂本裕司, 福西琢真, 倉田美恵, 倉田美恵, 青野潤, 黒部裕嗣, et al. 大動脈弁石灰化を制御する遺伝子の網羅的探索研究. 日本胸部外科学会定期学術集会(Web). 2023. 76th
坂上倫久, 坂上倫久, 菅野果歩, 濱口美香, 浪口謙治, 青野潤, 倉田美恵, 増本純也, 東山繁樹, 泉谷裕則. 大動脈弁石灰化に寄与する弁間質細胞の特性解析. 血管(Web). 2022. 45. 1
坂上倫久, 濱口美香, 青野潤, 薦田宗則, 福西琢真, 黒部裕嗣, 西村隆, 泉谷裕則. 大動脈弁石灰化におけるプロスタグランジン代謝経路の役割. 日本胸部外科学会定期学術集会(Web). 2022. 75th
坂上倫久, 坂上倫久, 濱口美香, 青野潤, 倉田美恵, 浪口謙治, 鹿田文昭, 山口修, 泉谷裕則. プロテオーム解析を用いた大動脈弁狭窄症治療標的候補分子の探索. 血管(Web). 2021. 44. 1
三角拓弥, 稲葉慎二, 東晴彦, 上谷晃由, 青野潤, 井上勝次, 池田俊太郎, 山口修. Frequency and features of guideline-based optimal medical treatment in patients with chronic heart failure: Insights from experience at Ehime University Graduate School of Medicine. 愛媛医学. 2021. 40. 3

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Education (2)：

2008 - 2012 Ehime University Graduate School of Medicine
1994 - 2000 Ehime University School of Medicine Faculty of Medicine

Professional career (1)：

医学博士 (愛媛大学)

Work history (10)：

2015/08 - 現在 Ehime University, Graduate School of Medicine Department of Cardiology, Pulmonology, Hypertension, and Nephrology Assistant Professor
2013/08 - 2015/07 University of Kentucky Saha Cardiovascular Research Center Postdoctoral scholar
2012/04 - 2013/07 喜多医師会病院循環器内科部長
2008/04 - 2012/03 Ehime University Graduate School of Medicine
2006/04 - 2008/03 市立宇和島病院循環器内科医長

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Awards (5)：

2018/09 - JCS 2018 Council Forum on Basic CardioVascular Research Best Poster Award
2014/11 - American Heart Association Scientific Sessions (AHA) 2014 ATVB Travel Awards for Young Investigators (ATVB Sessions 2014)
2014/11 - American Heart Association Scientific Sessions (AHA) 2014 ATVB Early Career Networking Reception
2011/03 - 愛媛大学愛媛大学大学院GP最優秀研究奨励賞
2010/12 - American Heart Association Scientific Sessions (AHA) 2010 ATVB Early Career Networking Reception

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