Ryoji Yoshida

Affiliation and department：
Other affiliations (1)：

歯科口腔外科学講座准教授

Research keywords (5)： Tumor microenvironment , Cancer stem cell , invasion/metastasis , Treatment resistance , Oral cancer

Research theme for competitive and other funds (6)：

2021 - 2024 Development of innovative therapies for oral cancer metastasis targeting the formation of pre-metastasis niches by exosomes
2018 - 2021 Elucidation and therapeutic application of tumor microenvironmental control mechanism by exosomes secreted by high-grade oral cancer
2017 - 2020 Relationship between antitumor immunity and lymph node immune environment in oral caner
2016 - 2018 Investigation of the mechanisms of regulating tumor microenvironment by secreted micro RNA from intractable oral cancer, and development a new treatment strategy
2014 - 2016 Functional analysis of oral cancer stem cell-related microRNAs and development of novel therapies

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Papers (127)：

Ryoji Yoshida, Riu Lin, Keisuke Yamana, Takeshi Obayashi, Hisashi Takeshita, Kosuke Shinohara, Kenta Kawahara, Masatoshi Hirayama, Nozomu Takahashi, Akiyuki Hirosue, et al. Pterygomandibular raphe invasion as a novel grading and prognostic factor for squamous cell carcinoma of buccal mucosa: a retrospective study with propensity score matching. International journal of clinical oncology. 2025. 30. 9. 1775-1786
Mayuko Yamashita, Hiromu Yano, Yoshihiro Komohara, Rin Yamada, Yukio Fujiwara, Masatoshi Hirayama, Yuki Seki, Ryoji Yoshida, Hideki Nakayama. Cytotoxic T Lymphocyte Density and PD-L1 Expression Predict the Response to Anti-PD1 Therapy in Recurrent Oral Squamous Cell Carcinoma. Microbiology and immunology. 2025. 69. 6. 350-358
Shizuka Morodomi, Akiyuki Hirosue, Akhinur Rahman, Kyotaro Nohata, Misaki Matsuo, Omnia Reda, Samiul Alam Rajib, Haruki Saito, Hiroki Takeda, Ryoji Yoshida, et al. Robust HPV-16 Detection Workflow for Formalin-Fixed Cancer Tissue and Its Application for Oral Squamous Cell Carcinoma. Cancer Medicine. 2025. 14. 4. e70544
Ryuta Kubo, Ryoji Yoshida, Rui Baba-Tajiri, Hibiki Nakamura-Yamada, Tomoya Miyahara, Toru Ooyama, Junki Inoue, Akiyuki Hirosue, Kenta Kawahara, Masafumi Nakamoto, et al. Differences in alveolar bone mineral density by tooth type in female osteoporotic patients treated with bisphosphonates. Oral Science International. 2025. 22. 1
Junki Inoue, Keisuke Yamana, Ryoji Yoshida, Yuki Seki, Kosuke Shinohara, Akiyuki Hirosue, Kenta Kawahara, Masafumi Nakamoto, Masatoshi Hirayama, Nozomu Takahashi, et al. Exosome-derived miR-1290 in blood as a predictive biomarker for occult neck metastasis in patients with cT1-2N0 tongue cancer. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2025

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MISC (279)：

竹下尚志, 吉田遼司, 中嶋光, 平山真敏, 川原健太, 廣末晃之. 顎矯正手術後に解離性障害を認めた1例. 日本顎変形症学会雑誌. 2024. 34. 2. 107-107
吉田遼司, 平山真敏, 廣末晃之, 川原健太, 中元雅史, 中村響, 久保隆太, 中山秀樹. 顎矯正手術中に三叉-迷走神経反射を生じた症例. 日本顎変形症学会雑誌. 2024. 34. 2. 108-108
平山真敏, 井上和繁, 犬童寛治, 竹下尚志, 中元雅史, 川原健太, 高橋望, 廣末晃之, 吉田遼司, 中山秀樹. オトガイ形成術を併用した上顎前歯部歯槽骨骨切り術の有用性についての検討. 日本顎変形症学会雑誌. 2024. 34. 2. 133-133
篠原光佑, 川原健太, 平山真弓, 轟祐誠, 井上淳貴, 関祐紀, 諸富静香, 吉田遼司, 中山秀樹. 口腔癌におけるシスプラチン耐性機構に関わるミトコンドリア形態とエネルギー産生. 頭頸部癌. 2024. 50. 2. 216-216
轟祐誠, 川原健太, 篠原光佑, 諸富静香, 山下真柚子, 関祐紀, 平山真弓, 吉田遼司, 中山秀樹. 口腔癌におけるパクリタキセルが及ぼすカルシウム動態とミトコンドリアの変化. 頭頸部癌. 2024. 50. 2. 216-216

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Lectures and oral presentations (121)：

予防的頸部郭清術はどのような症例で有用か?=Wait-and-Seeの観点から=
(日本口腔腫瘍学会総会・学術大会プログラム・抄録集 2019)
口腔扁平上皮癌におけるトシリズマブによる放射線感受性効果の検討
(日本口腔腫瘍学会総会・学術大会プログラム・抄録集 2019)
口腔扁平上皮癌のOsteopontin発現と放射線耐性に関する検討
(日本口腔腫瘍学会総会・学術大会プログラム・抄録集 2019)
当科における口腔腫瘍診療への3Dプリンターの活用
(日本口腔腫瘍学会総会・学術大会プログラム・抄録集 2019)
当科における再発・転移性口腔がんに対するNivolumabの使用経験
(日本口腔腫瘍学会総会・学術大会プログラム・抄録集 2019)

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Professional career (1)：

医学博士

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