Nagakubo Daisuke

ナガクボダイスケ | Nagakubo Daisuke

Affiliation and department：
Job title： Professor

Research field (1)： Experimental pathology

Research keywords (7)：外分泌腺 , 腸管上皮細胞 , 食品栄養学 , Chemokine , Allergy , Thymic epithelial cells , Immunology

Research theme for competitive and other funds (8)：

2020 - 2023 大腸粘液産生制御と創薬を目指した分子基盤の構築
2017 - 2020 Elucidation and control of immune cell infiltration mechanism involved in the pathogenesis of allergic rhinitis.
2016 - 2019 Molecular mechanisms and control of immune cell migration to skin and mucosa
2007 - 2009 Study on the pathophysiological role of the Th2-type chemokine receptor CCR4
2006 - 2007 ATLにおけるケモカイン受容体CCR4高頻度発現と発がん機構との関係の解明

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Papers (64)：

Daisuke Nagakubo, Yuichiro Kaibori. Oral Microbiota: The Influences and Interactions of Saliva, IgA, and Dietary Factors in Health and Disease. Microorganisms. 2023. 11. 9. 2307-2307
Yuichiro Kaibori, Kazuhiko Yamashita, Daisuke Nagakubo. The altered production and property of saliva induced by ingesting fermented food ingredients affect the oral microbiome composition in mice. Bioscience, Biotechnology, and Biochemistry. 2023. 87. 2. 228-235
Yuichiro Kaibori, Daisuke Nagakubo. CCR3 blockage elicits polyploidization associated with the signatures of epithelial-mesenchymal transition in carcinoma cell lines. Cancer Gene Therapy. 2023. 30. 1. 137-148
海堀祐一郎, 松尾一彦, 中山隆志, 長久保大輔. ケモカインCCL28はHippo経路を介して大腸杯細胞分化を誘導する. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 3P-229
Tatsuma Honzawa, Kazuhiko Matsuo, Shunya Hosokawa, Mayu Kamimura, Yuichiro Kaibori, Yuta Hara, Daisuke Nagakubo, Naoki Oiso, Akira Kawada, Atsushi Otsuka, et al. CCR4 plays a pivotal role in Th17 cell recruitment and expansion in a mouse model of rheumatoid arthritis. International immunology. 2022. 34. 12. 635-642

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MISC (42)：

西田晃尚, 山本真也, 松尾一彦, 早坂晴子, 海堀祐一郎, 長久保大輔, 原雄大, 義江修, 義江修, 中山隆志. Chemokine CCL28-mediated antitumor immunity against a murine melanoma. 日本薬学会年会要旨集(Web). 2023. 143rd
白川愛子, 長久保大輔, 稗島州雄, 中山隆志, 金哲, 義江修. 形質細胞におけるCCR10発現の活性型ビタミンD₃による誘導. 日本栄養・食糧学会大会講演要旨集. 2011. 65th. 105
Osamu Kaminuma, Akio Mori, Takayuki Ohtomo, Shin-ichi Sekizawa, Daisuke Nagakubo, Kunio Hieshima, Osamu Yoshie, Takachika Hiroi. Effect of CCR4 antagonist on T cell-mediated allergic airway inflammation in mice. FASEB JOURNAL. 2011. 25
神沼修, 大友隆之, 森晶夫, 長久保大輔, 稗島州雄, 義江修, 鈴木一矢, 廣井隆親. T細胞依存性の好酸球性気道炎症に対するCCR4拮抗薬の作用. アレルギー. 2009. 58. 8/9. 1206-1206
中野泰, 藤島清太郎, 長久保大輔, 君塚善文, 藤原宏, 鎌田浩史, 篠田裕美, 宮本京介, 田坂定智, 長谷川直樹, et al. C57/BLマウスのブレオマイシン(BLM)肺線維症モデルにおけるCCL17の役割. 日本呼吸器学会雑誌. 2009. 47. 260

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Education (3)：

1998 - 2002 大阪大学大学院医学系研究科分子病態医学専攻博士課程
1996 - 1998 北海道大学大学院薬学研究科製薬化学専攻修士過程
1992 - 1996 Hokkaido University Faculty of Pharmaceutical Sciences

Association Membership(s) (8)：

THE PHARMACEUTICAL SOCIETY OF JAPAN , THE JAPANESE CANCER ASSOCIATION , THE JAPANESE BIOCHEMICAL SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR IMMUNOLOGY , American Society for Biochemistry and Molecular Biology , 日本口腔ケア学会 , 日本農芸化学会

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