Rchr
J-GLOBAL ID:201601007524330090   Update date: May. 12, 2024

Yohei Hayashi

ハヤシ ヨウヘイ | Yohei Hayashi
Affiliation and department:
Job title: Team Leader (Principal Investigator)
Homepage URL  (2): https://acd.brc.riken.jp/ja/http://www.riken.jp/research/labs/brc/ips_cell_adv_char_dev/
Research field  (2): Medical biochemistry ,  Cell biology
Research keywords  (7): induced pluripotent stem cells ,  Embryonic Stem cells ,  Cellular Reprogramming ,  Differentiation ,  Disease Modeling ,  Reprogramming ,  iPS Cells
Research theme for competitive and other funds  (22):
  • 2023 - 2026 Cell fate decision by dose of transcription factors
  • 2021 - 2025 Phenotypic screening of genome-edited Induced pluripotent stem cells
  • 2021 - 2024 22q11.2症候群特異的iPS細胞由来神経堤の病態モデルでのゲノム編集応用
  • 2020 - 2023 胆道閉鎖症特異的iPS細胞を用いた胆管発生およびその障害メカニズムの解明
  • 2019 - 2022 Molecular dynamics of epigenomic transcriptional regulation by Klf4 in iPSC generation
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Papers (61):
  • Miyu Mori, Shoko Yoshii, Michiya Noguchi, Daigo Takagi, Tomoya Shimizu, Hidenori Ito, Mami Matsuo-Takasaki, Yukio Nakamura, Satoru Takahashi, Hiromichi Hamada, et al. Generation of human induced pluripotent stem cell lines derived from four Rett syndrome patients with MECP2 mutations. Stem Cell Research. 2024. 77. 103432-103432
  • Kana Yanagihara, Yohei Hayashi, Yujung Liu, Tomoko Yamaguchi, Yasuko Hemmi, Minako Kokunugi, Kozue Uchio Yamada, Ken Fukumoto, Mika Suga, Satoshi Terada, et al. Trisomy 12 compromises the mesendodermal differentiation propensity of human pluripotent stem cells. In vitro cellular & developmental biology. Animal. 2024
  • Koji Nakade, Satomi Tsukamoto, Kenichi Nakashima, Yuri An, Iori Sato, Jingyue Li, Yuzuno Shimoda, Yasuko Hemmi, Yoshihiro Miwa, Yohei Hayashi. Efficient selection of knocked-in pluripotent stem cells using a dual cassette cellular elimination system. Cell reports methods. 2023. 3. 12. 100662-100662
  • Mika Takahi, Riko Taira, Jo Onozuka, Haruka Sunamura, Akiko Kondow, Koji Nakade, Kenichi Nakashima, Iori Sato, Yohei Hayashi, Chinmoy Patra, et al. Xenograft of human pluripotent stem cell-derived cardiac lineage cells on zebrafish embryo heart. Biochemical and biophysical research communications. 2023
  • Pyotr A Tyurin-Kuzmin, Yohei Hayashi, Konstantin Kulebyakin. Editorial: Functional heterogeneity of stem cells. Frontiers in cell and developmental biology. 2023. 11. 1179911-1179911
more...
MISC (3):
  • Y. Hayashi, E. C. Hsiao, S. Sami, M. Lancero, C. R. Schlieve, T. Nguyen, K. Yano, A. Nagahashi, M. Ikeya, Y. Matsumoto, et al. BMP-SMAD-ID signaling axis supports reprogramming to pluripotency. MOLECULAR BIOLOGY OF THE CELL. 2012. 23
  • Hayashi Y, Hsiao E, Sami S, Lancero M, Schlieve C, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Asaka I, et al. BMP-SMAD-ID axis promotes reprogramming to pluripotency. 第10 回ISSCR(2012.6.14.横浜). 2012
  • Y. Hayashi, M. Furue, K. Ohnuma, M. Asashima. Laminin promotes differentiation of mouse embryonic stem cells in serum-free adherent monoculture. MECHANISMS OF DEVELOPMENT. 2005. 122. S129-S130
Books (5):
  • 動物実験代替法とNew approach methodologiesの開発・利用動向
    シーエムシー出版 2023 ISBN:9784781317472
  • 細胞培養・組織培養の技術
    朝倉書店 2023 ISBN:9784254310962
  • 細胞培養実習テキスト 第2版
    じほう 2020 ISBN:9784840752923
  • ~医薬品・再生医療製品開発者・技術者のための~iPS細胞の最新技術開発
    技術情報協会 2016
  • 細胞培養・品質管理の基礎知識と細胞培養基材の利用・開発・評価の留意点
    情報機構 2016
Lectures and oral presentations  (6):
  • iPS細胞における環状染色体の自己修復
    (第16回日本再生医療学会総会 2017)
  • Structure-based Discovery of NANOG Variant with Enhanced Properties to Promote Self-Renewal and Reprogramming of Pluripotent Stem Cells
    (第39回日本分子生物学会大会 2016)
  • 光応答性材料を介した光照射によるiPS細胞の分化操作
    (第8回TIAシンポジウム 2016)
  • Cell-Autonomous Correction of Ring Chromosomes in Human Induced Pluripotent Stem Cells
    (TERMIS (Tissue Engineering and Regenerative Medicine International Society) -AP (Asia & Pacific) 2016 2016)
  • 転写因子の構造解析から多能性幹細胞・リプログラミング機構の解明へ
    (生命の機能とかたち 筑波大学&高エネルギー加速器研究機構 第1回連携セミナー 2016)
more...
Education (3):
  • 2004 - 2009 The University of Tokyo Graduate School of Arts and Sciences Multi-Disciplinary Sciences Life Sciences
  • 2000 - 2004 The University of Tokyo, College of Arts and Sciences
  • 1997 - 2000 Okazaki High School
Professional career (1):
  • Ph. D. (University of Tokyo)
Work history (7):
  • 2022/07 - 現在 University of Tsukuba School of Integrative and Global Majors Professor
  • 2018/04 - 現在 RIKEN Bioresource Research Center Team Leader
  • 2016/04 - 2018/03 University of Tsukuba Graduate School of Comprehensive Human Sciences Assistant Professor
  • 2015/01 - 2015/03 Research Scientist at Gladstone Institute of Cardiovascular Disease
  • 2014/07 - 2015/03 Postdoctoral Fellow Overseas, Japanese Society for Promoting Sciences
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Committee career (7):
  • 2023/04 - 現在 バイオインダストリー協会 バイオエンジニアリング研究会 委員
  • 2023/04 - 現在 日本再生医療学会 産業推進委員会委員
  • 2018/11 - 現在 日本再生医療学会 代議員
  • 2021/06 - 日本再生医療学会 チームU45 メンバー
  • 2021/04 - 日本組織培養学会 理事
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Awards (10):
  • 2019/11 - The Science and technology Promotion Foundation of Ibaraki Tsukuba Encouragement Prize Young Researchers
  • 2018/04 - 筑波大学 筑波大学 若手教員特別奨励賞
  • 2018/04 - 文部科学省 平成30年度科学技術分野の文部科学大臣表彰 若手科学者賞
  • 2017/12 - 筑波大学 若手教員奨励賞
  • 2014/01 - 7th Takeda Science Foundation Symposium on PharmaScience Excellent Poster Award, 7th Takeda Science Foundation Symposium on PharmaScience
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Association Membership(s) (6):
バイオインダストリー協会 ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE TISSUE CULTURE ASSOCIATION ,  THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE ,  International Society for Stem Cell Research (ISSCR) ,  Tissue Engineering and Regenerative Medicine International Society (TERMIS)
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