Miki Kenji

ミキケンジ | Miki Kenji

Affiliation and department：

Research field (2)： Biomedical engineering , Cell biology

Research keywords (2)：小児心筋症 , 遺伝子治療

Research theme for competitive and other funds (7)：

2023 - 2026 臨床検体×空間オミクス解析×疾患iPS細胞の融合による拘束型心筋症の病態解明と治療法の探索
2023 - 2026 ヒトiPS細胞由来バイオ人工心臓の高機能化とスケールアップ
2023 - 2025 組織工学的アプローチによる心臓形態形成モデルの検証とその応用
2018 - 2021 Elucidation of the pathogenic mechanism of HCM using isogenic hiPSC-CMs with HCM mutation
2018 - 2020 Creation of an advanced HCM tissue model using human decellularized native extracellular matrix

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Papers (25)：

Misato Nakanishi-Koakutsu, Kenji Miki, Yuki Naka, Masako Sasaki, Takayuki Wakimizu, Stephanie C. Napier, Chikako Okubo, Megumi Narita, Misato Nishikawa, Reo Hata, et al. CD151 expression marks atrial- and ventricular- differentiation from human induced pluripotent stem cells. Communications Biology. 2024
Moyu Hasegawa, Kenji Miki, Takuji Kawamura, Ikue Takei Sasozaki, Yuki Higashiyama, Masaru Tsuchida, Kunio Kashino, Masaki Taira, Emiko Ito, Maki Takeda, et al. Gene correction and overexpression of TNNI3 improve impaired relaxation in engineered heart tissue model of pediatric restrictive cardiomyopathy. Development, growth & differentiation. 2024
Yuya Fujiwara, Kenji Miki, Kohei Deguchi, Yuki Naka, Masako Sasaki, Ayaka Sakoda, Megumi Narita, Sachiko Imaichi, Tsukasa Sugo, Shunsuke Funakoshi, et al. ERRγ agonist under mechanical stretching manifests hypertrophic cardiomyopathy phenotypes of engineered cardiac tissue through maturation. Stem cell reports. 2023
Wafa Altalhi, Tong Wu, Gregory R. Wojtkiewicz, Sydney Jeffs, Kenji Miki, Harald C Ott. Intra-tracheally injected human induced pluripotent stem cell-derived pneumocytes and endothelial cells engraft in the distal lung and ameliorate emphysema in a rat model. The Journal of Thoracic and Cardiovascular Surgery. 2023
Jun Jie Tan, Jacques P. Guyette, Kenji Miki, Ling Xiao, Gurbani Kaur, Tong Wu, Liye Zhu, Katrina J. Hansen, King-Hwa Ling, David J. Milan, et al. Human iPS-derived pre-epicardial cells direct cardiomyocyte aggregation expansion and organization in vitro. Nature Communications. 2021. 12. 1

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MISC (26)：

Shunsuke Funakoshi, Masaki Nomura, Chikako Okubo, Kenji Miki, Takeshi Kimura, Shinya Yamanaka, Akira Watanabe, Yoshinori Yoshida. Single Cell RNA Sequencing Reveals Dynamic and Heterogeneous Changes of Transcriptome During Cardiac Differentiation in vitro. CIRCULATION. 2014. 130
Shunsuke Funakoshi, Kenji Miki, Takeshi Kimura, Shinya Yamanaka, Yoshinori Yoshida. Very High Engraftment, Proliferation, and Therapeutic Potential of IPSC-Derived Cardiomycytes. CIRCULATION. 2014. 130
Kenji Miki, Seiya Takahashi, Shunsuke Funakoshi, Shinya Yamanaka, Hirohide Saito, Yoshinori Yoshida. A Novel Purification Method for Cardiomyocytes and Endothelial Cells Derived From Human Pluripotent Stem Cells Using Micrornaresponsive Messenger Rna. CIRCULATION. 2014. 130
Masashi Kawamura, Shigeru Miyagawa, Satsuki Fukushima, Atsuhiro Saito, Yukiko Imanishi, Emiko Ito, Nagako Sougawa, Kenji Miki, Takuji Kawamura, Masaru Ishida, et al. Enhanced Therapeutic Effects of Human iPS Cell Derived Cardiomyocyte Transplantation by the Combination of Cell Sheets With the Pedicle Omental Flap Technique in a Porcine Ischemic Cardiomyopathy Model. CIRCULATION. 2013. 128. 22
Masashi Kawamura, Shigeru Miyagawa, Satsuki Fukushima, Kenji Miki, Atsuhiro Saito, Koichi Toda, Hiroyuki Nishi, Yasushi Yoshikawa, Takayoshi Ueno, Toru Kuratani, et al. Development of Vascular-Rich Tissue Containing Cardiomyocytes Derived from Human iPS Cells in vivo. CIRCULATION. 2012. 126. 21

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Patents (13)：

細胞の製造方法
心筋細胞成熟促進剤
複素環化合物
組織細胞の選別方法
組織細胞の選別方法

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Lectures and oral presentations (8)：

Generation of human iPSC-derived mature cardiomyocytes and its applications
(The 5th Monash University - Osaka University Joint Symposium on Advanced Biomedical Sciences 2023)
ERRG AGONIST AND SKP2 INHIBITOR ARE NOVEL MATURATION FACTORS IN HUMAN IPSC-DERIVED CARDIOMYOCYTES
(The International Society for Stem Cell Research 16th Annual Meeting 2018)
Application of miRNA switches to regenerative medicine and disease modeling
(2017)
A NOVEL CLINICALLY APPLICABLE METHOD FOR PURIFICATION OF HUMAN PLURIPOTENT STEM CELL DERIVED CELLS USING MICRORNA RESPONSIVE SYNTHETIC MRNAS
(The International Society for Stem Cell Research 13th Annual Meeting 2015)
Synthetic mRNA switches for detection and purification of cardiomyocytes and endothelial cells derived from human pluripotent stem cells
(第79回日本循環器学会 2015)

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Work history (4)：

2023/04 - 現在 Osaka University
2019/09 - 2023/03 Massachusetts General Hospital
2015/10 - 2019/08 京都大学iPS細胞研究所 T-CiRAプログラム特定助教
2012/10 - 2015/09 京都大学iPS細胞研究所特定研究員

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