Rchr
J-GLOBAL ID：201601009483590599   Update date: Apr. 23, 2024

Takatsugu Ishimoto

Takatsugu Ishimoto
Affiliation and department：
Japanese Foundation for Cancer Research Division of Carcinogenesis

About Japanese Foundation for Cancer Research Division of Carcinogenesis


Job title： Chief
Other affiliations (1)：
Research field  (1)： Tumor biology
Research keywords  (4)： Cancer Stem Cells ,  Cancer Related Inflammation ,  Tumor Microenvironment ,  Gastric Cancer
Research theme for competitive and other funds  (34)：
  • 2023 - 2026 JNKシグナル制御による免疫抑制的腫瘍微小環境の克服
  • 2023 - 2026 遠隔臓器コミュニケーションによるスキルス胃癌線維化メカニズムの解明
  • 2023 - 2026 腫瘍間質に依存したシェアストレス抵抗性の獲得と血行性がん転移機構の解明
  • 2022 - 2025 がんーストローマ代謝物クロストークによる膵癌進展メカニズムの解明
  • 2023 - 2025 線維化腫瘍に対する複合がん免疫療法の効果予測バイオマーカー確立
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Papers (238)：
  • Jun Zhang, Lingfeng Fu, Huaitao Wang, Atsuko Yonemura, Takashi Semba, Noriko Yasuda-Yoshihara, Akiho Nishimura, Takuya Tajiri, Yilin Tong, Tadahito Yasuda, et al. RAC1-mediated Integrin alpha-6 expression in E-cadherin-deficient gastric cancer cells promotes interactions with the stroma and peritoneal dissemination. Cancer letters. 2024. 216901-216901
  • Atsuko Yonemura, Takashi Semba, Jun Zhang, Yibo Fan, Noriko Yasuda-Yoshihara, Huaitao Wang, Tomoyuki Uchihara, Tadahito Yasuda, Akiho Nishimura, Lingfeng Fu, et al. Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment. Cell reports. 2024. 43. 1. 113613-113613
  • Keisuke Kosumi, Yoshifumi Baba, Yoshihiro Hara, Haolin Wang, Daichi Nomoto, Tasuku Toihata, Mayuko Ohuchi, Kazuto Harada, Kojiro Eto, Katsuhiro Ogawa, et al. Body Composition and Clinical Outcomes in Esophageal Cancer Patients Treated with Immune Checkpoint Inhibitors. Annals of Surgical Oncology. 2024
  • Yoshifumi Baba, Noriko Yasuda, Miki Bundo, Yutaka Nakachi, Junko Ueda, Takatsugu Ishimoto, Masaaki Iwatsuki, Yuji Miyamoto, Naoya Yoshida, Hiroyuki Oshiumi, et al. LINE-1 hypomethylation, increased retrotransposition and tumor-specific insertion in upper gastrointestinal cancer. Cancer Science. 2023
  • Fumimasa Kitamura, Takashi Semba, Noriko Yasuda-Yoshihara, Kosuke Yamada, Akiho Nishimura, Juntaro Yamasaki, Osamu Nagano, Tadahito Yasuda, Atsuko Yonemura, Yilin Tong, et al. Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer. JCI insight. 2023. 8. 20
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MISC (503)：
  • Yuki Sakamoto, Kosuke Mima, Hiroshi Sawayama, Katsunori Imai, Masaaki Iwatsuki, Takatsugu Ishimoto, Yoshifumi Baba, Shiro Iwagami, Yuji Miyamoto, Yo-ichi Yamashita, et al. Fusobacterium nucleatum, CD8+T cells and myeloid derived suppressor cells in colorectal cancer liver metastasis. CANCER SCIENCE. 2021. 112. 795-795
  • Daichi Nomoto, Yoshifumi Baba, Takahiko Akiyama, Takeshi Morinaga, Kazuo Okadome, Kohei Yamashita, Yuki Sakamoto, Tomoya Daitoku, Tasuku Toihata, Hiroshi Sawayama, et al. Fusobacterium nucleatum promotes progression of esophageal squamous cell carcinoma via NF-kB pathway. CANCER SCIENCE. 2021. 112. 622-622
  • Fumimasa Kitamura, Takatsugu Ishimoto, Takahiko Akiyama, Kazuki Matsumura, Norio Uemura, Tadahito Yasuda, Yosuke Nakao, Toshihiko Yusa, Rumi Itouyama, Katsunori Imai, et al. LDH expression in pancreatic cancer enhances the fibrotic tumor stroma. CANCER SCIENCE. 2021. 112. 811-811
  • ヤスダ タダヒト, ババ ヒデオ, イシモト タカツグ. 消化管幹細胞の寛容性とニッチによるホメオスタシスの維持. 2021. 72. 2. 109-112
  • 長井洋平, 石本崇胤, 今井克憲, 野元大地, 馬場祥史, 岩槻政晃, 宮本英明, 具嶋亮介, 直江秀昭, 伊牟田真功, et al. 進行食道癌におけるステントと緩和的手術の使い分け~現状と課題~. Gastroenterological Endoscopy (Web). 2020. 62. Supplement1
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Patents (2)：
Education (2)：
  • 2005 - 2009 Kumamoto University Graduate School of Medical Sciences Faculty of Medicine
  • 1995 - 2001 Kumamoto University Graduate School of Medical Sciences
Professional career (1)：
  • 博士(医学) (熊本大学)
Work history (9)：
  • 2023/08 - 現在 The Cancer Institute, Japanese Foundation for Cancer Research Division of Carcinogenesis Chief
  • 2023/08 - 現在 熊本大学 国際先端医学研究機構 客員教授
  • 2023/04 - 2023/07 熊本大学 国際先端医学研究機構 特任教授
  • 2017/09 - 2023/03 Kumamoto University International Research Center of Medical Sciences (IRCMS)
  • 2017/09 - 2023/03 Kumamoto University Gastroenterological Surgery Associate Professor
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Awards (7)：
  • 2020 - 消化器癌発生学会 田原榮一賞
  • 2019 - AACR- KCA joint work shop Young Investigator Scholarship
  • 2017 - 日本胃癌学会 優秀研究賞
  • 2015 - 日本消化器外科学会 Young Investigator of the Year 2015
  • 2013 - 上原記念財団 海外留学リサーチフェローシップ
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