Rchr
J-GLOBAL ID：201601010069884732
Update date: Sep. 19, 2025
Horigane Shin'ichiro
ホリガネ シンイチロウ | Horigane Shin'ichiro
Affiliation and department：
Job title：
Lecturer
Other affiliations (2)：
Research field (2)：
Neuropathology
, Neuroscience - general
Research keywords (6)：
Neurodevelopmental disorders
, Voltage dependent Ca2+ channels (VDCCs)
, Live imagign
, Neuronal migration
, Calcium signaling
, Neuronal circuit formation
Research theme for competitive and other funds (8)：
- 2025 - 2028 神経シナプスマッピングによる発達障害の病態解明および治療探索
- 2024 - 2027 カルシウムチャネル異常に起因する自閉スペクトラム症の病態解明と治療開発
- 2022 - 2024 Deciphering inhibitory neural circuit abnormality underlying autism spectrum disorder and investigation of a new therapeutic approach
- 2022 - 2023 自閉スペクトラム症に合併する運動機能障害に対する新たな治療戦略の開発
- 2020 - 2022 カルシウムシグナリング破綻に着目した自閉スペクトラム症における神経回路病態の解明
- 2019 - 2021 新規病態モデルを用いた多角的解析による発達障害の神経回路病態解明
- 2019 - 2021 自閉スペクトラム症の病態理解にむけたカルシウムシグナリング破綻を原因とする神経回路形成障害の解明
- 2012 - 2015 CaMKK-CaMKIカスケードを介した神経細胞移動制御
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Papers (16)：
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Miao Pan, Pin-Wu Liu, Yukihiro Ozawa, Fumiko Arima-Yoshida, Geyao Dong, Masahito Sawahata, Daisuke Mori, Masashi Nagase, Hajime Fujii, Shuhei Ueda, et al. A hyper-activatable CAMK2A variant associated with intellectual disability causes exaggerated long-term potentiation and learning impairments. Translational Psychiatry. 2025
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Shin-ichiro Horigane, Sayaka Takemoto-Kimura. Ca2+ Imaging in Immature Cortical Neurons. Methods in Molecular Biology. 2024. 211-219
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Hajime Fujii, Hiroyuki Kidokoro, Yayoi Kondo, Masahiro Kawaguchi, Shin-ichiro Horigane, Jun Natsume, Sayaka Takemoto-Kimura, Haruhiko Bito. Förster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca2+/calmodulin-dependent CaMKIIα activity in de novo mutations related to intellectual disability. Frontiers in Molecular Neuroscience. 2022. 15. 970031-970031
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Chenyao Wang*, Shin-ichiro Horigane*, Minoru Wakamori*, Shuhei Ueda, Takeshi Kawabata, Hajime Fujii, Itaru Kushima, Hiroki Kimura, Kanako Ishizuka, Yukako Nakamura, et al. Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder. Translational psychiatry. 2022. 12. 1. 84-84
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Masayuki Sakamoto, Masatoshi Inoue, Atsuya Takeuchi, Shigetaka Kobari, Tatsushi Yokoyama, Shin-ichiro Horigane, Sayaka Takemoto-Kimura, Manabu Abe, Kenji Sakimura, Masanobu Kano, et al. A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo. Cell Reports Methods. 2022. 100168-100168
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MISC (2)：
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堀金慎一郎. 放射状移動中の大脳皮質興奮性神経細胞におけるL型カルシウムチャネル依存的な一過的細胞内カルシウム濃度上昇の発達. 神経科学ニュース. 2022
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HORIGANE Shin-ichiro, Sayaka Takemoto-Kimura. Intracellular Ca2+ signaling regulates neuronal migration in the developmental period. 2019. 30. 1
Patents (2)：
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Timothy症候群のモデル動物
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細胞内カルシウム動態評価系
Lectures and oral presentations (12)：
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Ca2+ signalling drives nuclear deformation cycles in radially migrating cortical neurons
(The 68th Annual Meeting of the Japanese Society for Neurochemistry 2025)
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Polarized Ca2+ signalling drives neuronal nuclear deformation cycles underlying morphogenetic shape shift during cortical radial migration
(Neuro2024 2024)
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Polarized Ca2+ signalling drives neuronal nuclear deformation cycles underlying morphogenetic shape shift during cortical radial migration
(2024)
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Polarized Ca2+ transients via voltage-gated Ca2+ channels control cyclic nuclear deformation underlying cortical radial migration
(2023)
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胎生期の脳内を移動する神経細胞 ~神経細胞の緻密な脳内配置決定~
(2022年度 環境医学研究所 市民公開講座 2022)
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Professional career (1)：
Work history (5)：
- 2020/10 - 現在 Nagoya University Research Institute of Environmental Medicine Associate professor/lecturer
- 2016/03 - 2020/09 Nagoya University Research Institute of Environmental Medicine Assistant Professor
- 2015/09/01 - 2016/02/29 Nagoya University Research Institute of Environmental Medicine
- 2015/04 - 2015/08 The University of Tokyo Graduate School of Medicine
- 2012/04 - 2015/03 日本学術振興会特別研究員(DC1)
Association Membership(s) (3)：
日本神経科学会
, Society for Neuroscience
, The Japanese Society for Neurochemistry
