Rchr
J-GLOBAL ID:201601010695229908   Update date: Aug. 18, 2023

Makoto Taniguchi

タニグチ マコト | Makoto Taniguchi
Affiliation and department:
Job title: 講師
Homepage URL  (1): https://kaken.nii.ac.jp/d/r/30529433.ja.html
Research field  (2): Molecular biology ,  Cell biology
Research keywords  (11): Cell biology ,  Molecular Biology ,  plasma membrane ,  Viral infection ,  cancer ,  Lipid biochemistry ,  Sphongolipids ,  Ceramide ,  Lipid raft ,  Sphingomyelin synthase ,  Sphingomyelin
Research theme for competitive and other funds  (7):
  • 2022 - 2025 スフィンゴミエリン合成酵素2阻害剤による腫瘍免疫亢進を介した新規抗癌治療の開発
  • 2021 - 2024 血小板膜におけるスフィンゴミエリンを介したリン脂質露呈制御機構の解明
  • 2020 - 2023 SMS阻害による癌微小環境免疫療法の分子機構解明
  • 2016 - 2019 スフィンゴミエリン/脂質ラフトを標的としたインプラント周囲炎の新たな予防法の開発
  • 2017 - 2019 スフィンゴミエリン合成酵素欠損による急性骨髄性白血病進行の抑制機構の解明
Show all
Papers (44):
  • Mao Kondo, Koki Kimura, Jingjing Kobayashi-Sun, Shiori Yamamori, Makoto Taniguchi, David Traver, Isao Kobayashi. The sinusoidal hematopoietic niche is formed by Jam1a via Notch signaling in the zebrafish kidney. iScience. 2023. 26. 4. 106508
  • Makoto Taniguchi, Shingo Nagaya, Kohei Yuyama, Ai Kotani, Yasuyuki Igarashi, Toshiro Okazaki. Ceramide Metabolism Regulated by Sphingomyelin Synthase 2 Is Associated with Acquisition of Chemoresistance via Exosomes in Human Leukemia Cells. International Journal of Molecular Sciences. 2022. 23. 18. 10648
  • Jun Fujita, Makoto Taniguchi, Chieko Hashizume, Yoshibumi Ueda, Shota Sakai, Tadakazu Kondo, Mayumi Hashimoto-Nishimura, Kentaro Hanada, Takeo Kosaka, Toshiro Okazaki. Nuclear Ceramide Is Associated with Ataxia Telangiectasia Mutated Activation in the Neocarzinostatin-Induced Apoptosis of Lymphoblastoid Cells. Molecular pharmacology. 2022. 101. 5. 322-333
  • Makoto Taniguchi, Toshiro Okazaki. Role of ceramide/sphingomyelin (SM) balance regulated through “SM cycle” in cancer. Cellular Signalling. 2021. 87. 110119
  • Yoritaka Fujii, Makoto Taniguchi, Shingo Nagaya, Yoshibumi Ueda, Chieko Hashizume, Ken Watanabe, Hiroyuki Takeya, Takeo Kosaka, Toshiro Okazaki. A novel mechanism of thrombocytopenia by PS exposure through TMEM16F in sphingomyelin synthase 1 deficiency. Blood advances. 2021. 5. 20. 4265-4277
more...
MISC (22):
Patents (1):
  • 造血器腫瘍治療剤、およびスクリーニング方法
Lectures and oral presentations  (35):
  • 白血病細胞におけるスフィンゴミエリン合成酵素2によるセラミド代謝を介したエクソソーム放出と抗がん剤耐性能獲得について
    (第15回セラミド研究会・第16回スフィンゴテラピィ研究会合同年会 2022)
  • Ceramide/sphingomyelin balance regulated by sphingomyelin synthase in murine disease models.
    (The 141st Annual Meeting of the Pharmaceutical Society of Japan 2021)
  • Deficiency of sphingomyelin synthase 2 prolongs survival by inhibition of lymphoma infiltration through ICAM-1 reduction
    (第14回スフィンゴテラピィ研究会 2020)
  • Deficiency of sphingomyelin synthase 2 prolongs survival by inhibition of lymphoma infiltration through ICAM-1 reduction
    (第55回金沢医科大学 医学会学術集会 2019)
  • Deficiency of SMS2 suppresses the infiltration of EL4 T lymphoma cells through ICAM-1 reduction
    (第13回スフィンゴテラピィ研究会 2018)
more...
Education (1):
  • 2003 - 2006 Tottori University Faculty of Medicine Division of Molecular Biology
Work history (4):
  • 2014/04 - 現在 Kanazawa Medical University Medical Research Institute Lecturer
  • 2012/06 - 2014/03 Kanazawa Medical University Medical Research Institute Assistant Professor
  • 2010/09 - 2012/05 Tottori University Faculty of Medicine PostDoc
  • 2006/04 - 2010/08 Tottori University Faculty of Medicine PostDoc
Committee career (1):
  • 2019/08 - 現在 スフィンゴテラピィ研究会 組織委員(事務局長)
Awards (3):
  • 2022/03 - 金沢医科大学総合医学研究所 令和3年度研究セミナー 奨励賞
  • 2021/03 - 金沢医科大学総合医学研究所 令和2年度研究セミナー 所長賞
  • 2017/01 - 金沢医科大学 優良教員賞(研究活動部門)
Association Membership(s) (2):
JAPANESE SOCIETY OF RADIATION SAFETY MANAGEMENT ,  THE JAPANESE BIOCHEMICAL SOCIETY
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