Rchr
J-GLOBAL ID：201601011448590459   Update date: Sep. 26, 2024

Takeda Mitsuhiro

タケダ ミツヒロ | Takeda Mitsuhiro
Affiliation and department：
Kumamoto University

About Kumamoto University


Job title： Assistant Professor
Research field  (1)： Structural biochemistry
Research theme for competitive and other funds  (11)：
  • 2020 - 2023 NMR・MRIに基づくシステインを介する生体内分子置換反応の解明
  • 2020 - 2023 MRIを用いた匂い・フェロモンと行動等の嗅覚応答を関連づける情報処理機構の解明
  • 2020 - 2023 脳組織に定着した神経細胞内における認知症病原タンパク質のMRI解析
  • 2017 - 2020 MRIによる認知症病原蛋白質のオリゴマー構造の解析
  • 2016 - 2018 Analyses of the oligomers of amyloid beta by NMR/MRI and protein science
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Papers (52)：
  • Yohei Miyanoiri, Mitsuhiro Takeda, Kosuke Okuma, Tsutomu Terauchi, Masatsune Kainosho. Enhancing solution structural analysis of large molecular proteins through optimal stereo array isotope labeling of aromatic amino acids. Biophysical Chemistry. 2024. 107328-107328
  • Takayuki Nagae, Mitsuhiro Takeda, Tomoyasu Noji, Keisuke Saito, Hiroshi Aoyama, Yohei Miyanoiri, Yutaka Ito, Masatsune Kainosho, Yuu Hirose, Hiroshi Ishikita, et al. Direct evidence for a deprotonated lysine serving as a H-bond “acceptor” in a photoreceptor protein. Proceedings of the National Academy of Sciences. 2024. 121. 36
  • Mitsuhiro Takeda, Yohei Miyanoiri, Tsutomu Terauchi, Masatsune Kainosho. Conformational features and ionization states of Lys side chains in a protein studied using the stereo-array isotope labeling (SAIL) method. Magnetic Resonance. 2021. 2. 1. 223-237
  • Tatsuichiro Tsuji, Sosuke Yoshinaga, Mitsuhiro Takeda, Takafumi Sato, Akihiro Sonoda, Norihito Ishida, Kaori Yunoki, Etsuko Toda, Yuya Terashima, Kouji Matsushima, et al. Rational Design of Monodispersed Mutants of Proteins by Identifying Aggregation Contact Sites Using Solubilizing Agents. Biochemistry. 2020. 59. 39. 3639-3649
  • Yohei Miyanoiri, Mitsuhiro Takeda, Tsutomu Terauchi, Masatsune Kainosho. Recent developments in isotope-aided NMR methods for supramolecular protein complexes -SAIL aromatic TROSY. Biochimica et biophysica acta. General subjects. 2020. 1864. 2. 129439-129439
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MISC (17)：
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Books (3)：
  • Experimental Approaches of NMR Spectroscopy, 2 Isotope-Aided Methods for Biological NMR Spectroscopy: Past, Present, and Future
    Springer 2018
  • Comprehensive Biophysics Volume 1: Biophysical Techniques for Structural Characterization of Macromolecules, 1.12 Labeling Techniques
    Elsevier 2012
  • Protein NMR Spectroscopy: Principle Techniques and Applications
    Wiley 2011
Lectures and oral presentations  (53)：
  • NMR同位体シフト効果を利用したタンパク質に含まれるリジン残基側鎖アミノ基の脱プロトン化状態の可視化
    (日本薬学会第144年会 2024)
  • タンパク質の側鎖官能基に隣接した13Cに誘起されるH/D同位体シフト効果の大きさに基づいた官能基の脱プロトン化状態の可視化
    (第62回NMR討論会 2023)
  • 匂いと行動を関連づける脳活性化経路の機能的MRI:ムスク臭により誘因刺激したマウスの脳活性化部位の解析
    (日本磁気共鳴医学会 前臨床MRIスタディグループ 2021 2021)
  • Attempts to improve spectral quality using aggregation-suppressed mutant proteins for in-cell NMR
    (2021)
  • fMRI study of brain activation pathways connecting odor stimulation and behaviors: Analysis of activations evoked by attractive odor, muscone
    (2021)
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Education (1)：
  • 2000 - 2005 The University of Tokyo Graduate School of Pharmaceutical Sciences
Professional career (1)：
  • 博士(薬学) (東京大学)
Work history (5)：
  • 2023/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Lecturer
  • 2015/04 - 2023/03 Kumamoto University Faculty of Life Sciences, Structural BioImaging Assistant Professor,
  • 2011/08 - 2015/03 Nagoya University
  • 2007/02 - 2011/07 Nagoya University
  • 2005/04 - 2007/01 科学技術振興機構CREST研究員
Association Membership(s) (4)：
JAPANESE SOCIETY FOR MAGNETIC RESONANCE IN MEDICINE ,  THE BIOPHYSICAL SOCIETY OF JAPAN ,  THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN ,  日本分子イメージング学会
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