Nishiyama Nobuhiro

ニシヤマノブヒロ | Nishiyama Nobuhiro

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Tokyo Institute of Technology Interdisciplinary Graduate School of Science and Engineering

Research field (1)： Biomaterials

Research keywords (3)： Nanomedicine , Drug Delivery System , Biomaterials Science

Research theme for competitive and other funds (34)：

2022 - 2026 Development of polymeric micelles based on innovative core-shell design for various therapeutic modalities
2021 - 2024 A New Photodynamic Therapy System for Deep Organ Cancer Using an Implantable Light-Emitting Device
2018 - 2022 Development of smart polymeric micelles based on novel shell and core designs
2017 - 2020 Highly efficient cancer treatment system combined with a drug-delivery photoabsorbent agent and a tempreature-controled laser system
2016 - 2019 診断分子と治療分子を搭載したセラノスティック型ナノDDSの創製

2016 - 2019 深部がんのイメージングおよび標的治療を可能にする高分子ナノデバイスの創製

2016 - 2018 Development of innovative nucleic acid medicine for gastroenterological cancer

2016 - 2018 Design of functional polymers responsive to tumor microenvironment and their applications for diagnosis and therapy

2015 - 2018 Design of functional ligand molecules focused on specific metabolism of cancer cells and their applications for diagnosis and therapy

2015 - 2017 New construction of in vivo reprogramming technology by modified microRNA

2014 - 2017 New construction of innovative drug discovery foundation technology for refractory gastrointestinal cancer targeting cancer metabolomics

2013 - 2017 Development of Polymeric Micelles for Brain-Targeted Delivery of Nucleic Acid Drugs to Treat Intractable Neurological Diseases

2013 - 2015 Development of smart MRI contrast agents based on polymeric micelles to detect tumor microenvironment

2013 - 2015 固形がんの特異的イメージングのためのMRI造影剤搭載ナノデバイスの研究開発

2012 - 2015 Development of efficient drug and gene delivery system for malignant brain tumors using polymeric nanomicelles.

2011 - 2015 Development of systemically injectable siRNA delivery systems by fine-tuning of block copolymers

2011 - 2014 Theranostic system for cancer by the combination of supramolecular nanocarriers with optical technology

2012 - 2013 環境応答性と標的指向性を兼備した機能性DDSの開発

2009 - 2011 Development of Novel Therapeutic Angiogenesis Method by Combination of Nanotechnology and siRNA Targeting PHD2

2009 - 2011 Development of selective and efficient drug delivery system for malignant brain tumors using polymeric nanomicelles.

2009 - 2011 Multidiciplinary TNF・a based gene therapy using polyplex micelle

2009 - 2010 生体内環境耐性と応答性を兼備したリピド被覆型高分子ミセルドラッグ

2008 - 2010 Novel approach for management of age-related macular degeneration using nanotechnology

2008 - 2010 Development of multifunctional polymeric micelles for systemic siRNA delivery

2007 - 2009 Innovative nano-therapy based on nanocarriers equipped with the ability to circumvent biological barriers

2007 - 2009 Strategic development of a novel implant system to achieve bone regeneration without cell transplantation

2005 - 2009 Polymeric micelle nanocarrier for drug and gene delivery

2006 - 2007 Novel Approach for Brain Tumor Treatment using Nano-micelle Drug Delivery System

2005 - 2007 Development of functional polymeirc micelles responding to intracellular microenvironments for cancer chemotherapy

2005 - 2006 Development of application of compact tunable monochromatic X-ray source

2004 - 2006 部位選択的な遺伝子治療のための光を利用した新規ナノ医療システムの創製

2004 - 2005 Nano-micelle Drug Delivery System for the Treatment of Brain Tumors

2004 - 2005 Novel tissue regeneration using polymer nano-micelle gene delivery system

2003 - 2005 New support system of vascular surgery using novel bio-materials

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Papers (372)：

Masahiro Toyoda, Yutaka Miura, Motoaki Kobayashi, Masato Tsuda, Takahiro Nomoto, Yuto Honda, Hiroyuki Nakamura, Hiroyasu Takemoto, Nobuhiro Nishiyama. Synthesis and Optimization of Ethylenediamine-Based Zwitterion on Polymer Side Chain for Recognizing Narrow Tumorous pH Windows. Biomacromolecules. 2024
Daiki Tokura, Kakeru Konarita, Minoru Suzuki, Keisuke Ogata, Yuto Honda, Yutaka Miura, Nobuhiro Nishiyama, Takahiro Nomoto. Active control of pharmacokinetics using light-responsive polymer-drug conjugates for boron neutron capture therapy. Journal of controlled release : official journal of the Controlled Release Society. 2024. 371. 445-454
Ryosuke Sonobe, Peng Yang, Miho M. Suzuki, Keiko Shinjo, Kenta Iijima, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka, Hiroaki Kajiyama, Yutaka Kondo. Long noncoding RNATUG1 promotes cisplatin resistance in ovarian cancer via upregulation of DNA polymerase eta. Cancer Science. 2024
Keitaro Homma, Yutaka Miura, Motoaki Kobayashi, Wanphiwat Chintrakulchai, Masahiro Toyoda, Koichi Ogi, Junya Michinishi, Tomoyuki Ohtake, Yuto Honda, Takahiro Nomoto, et al. Fine tuning of the net charge alternation of polyzwitterion surfaced lipid nanoparticles to enhance cellular uptake and membrane fusion potential. Science and technology of advanced materials. 2024. 25. 1. 2338785-2338785
Makoto Matsui, Yuka Kaihara, Yuto Honda, Nobuhiro Nishiyama, Yutaka Miura. Site-activatable targeting of macromolecular alendronate for accelerated fracture healing. Science and Technology of Advanced Materials. 2023. 24. 1

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MISC (198)：

本田雄士, 野本貴大, 西山伸宏. Sequential Self-assembly Bio-building Blocks Based on Polyphenol Materials for Efficient Biomolecule Delivery. バイオマテリアル(Web). 2023. 41. 1
本田雄士, 本田雄士, 本田雄士, シャイクリザルエルムツタキン, 西山伸宏, 西山伸宏, 野本貴大, 野本貴大. ボロン酸エステルを基盤とした細胞内相転移による高分子-細胞間相互作用制御および薬物送達キャリアとしての応用. 日本DDS学会学術集会プログラム予稿集. 2023. 39th
松平望, 松平望, 本田雄士, 本田雄士, 長尾周平, 長尾周平, 喜納宏昭, 野本貴大, 野本貴大, 三浦裕, et al. 腫瘍標的機能を備えた環状ペプチド搭載アデノ随伴ウイルス(AAV)三元系複合体の開発. 日本DDS学会学術集会プログラム予稿集. 2023. 39th
バトバヤルアヌダリ, 本田雄士, 野本貴大, 三浦裕, 西山伸宏. タンニン酸とフェニルボロン酸導入高分子から形成されるオボアルブミン内包三元系複合体の構築とがんワクチンアジュバントとしての応用. 日本DDS学会学術集会プログラム予稿集. 2023. 39th
小林基晃, 小林基晃, GHASEMIZADEH Aria, GHASEMIZADEH Aria, 豊田真広, 豊田真広, CHINTRAKULCHAI Wanphiwat, CHINTRAKULCHAI Wanphiwat, SUNG Yijung, SUNG Yijung, et al. ポリベタイン修飾脂質ナノ粒子を用いたpH変化をトリガーとする腫瘍選択的siRNA送達システムの開発. 日本DDS学会学術集会プログラム予稿集. 2023. 39th

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Work history (7)：

2015/04 - 現在 Tokyo Institute of Technology
2013/01 - 2015/03 Tokyo Institute of Technology
2009/09 - 2013/12 The University of Tokyo
2006/06 - 2009/08 The University of Tokyo
2004/04 - 2006/05 The University of Tokyo

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Awards (5)：

2019 - 文部科学省科学技術分野の文部科学大臣表彰科学技術賞(研究)
2016 - 一般財団法人新製剤技術とエンジニアリング振興基金第3回パーティクルデザイン賞
2012 - 日本癌学会奨励賞
2009 - 第一回日本DDS学会奨励賞(基礎)
2007 - 高分子学会高分子研究奨励賞

Association Membership(s) (5)：

日本分子イメージング学会 , 日本バイオマテリアル学会 , 高分子学会 , 日本癌学会 , 日本DDS学会

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