2015 - 2018 Investigation of the molecular mechanisms underlying therapeutic resistance in osteosarcoma metastasis
2014 - 2018 次世代の’包括的緩和医療’を支える最先端基礎/臨床融合型研究の基盤形成
2012 - 2015 Investigation and conquest of the therapeutic resistant dormancy in osteosarcoma mediated by insulin-like growth factor (IGF) signaling
2014 - 2015 難治性間葉系腫瘍(骨肉腫)の生体内悪性化分子機構の解明とその克服
2012 - 2013 インスリン様成長因子による骨肉腫治療誘導型休眠状態の分子機構解明と克服
2012 - 2013 Elucidation of molecular functions of Imp3 in osteosarcoma progression, and development of novel anti-Imp3 targeted therapeutic approach
2010 - 2011 Investigation of the roles of tumor environment in osteosarcoma
2008 - 2009 Establishment and analysis of mouse tumor models from multipotent bone marrow stromal cells overexpressing c-MYC
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Papers (49)：
Ayaka Kunishima, Takatsune Shimizu, Tetsuya Takimoto, Atsunobu Sagara, Hiroyuki Nobusue, Hidetoshi Hasuwa, Shinya Hasegawa, Yuka Tamaoki, Hitomi Miyake, Yumi Fukuchi, et al. Depleting HIF-1α attenuates the progression of osteosarcoma, but tumorigenicity is sustained through HIF-independent pathways. Oncology reports. 2026. 55. 5
Atsunobu Sagara, Tomofumi Watanabe, Tomoya Abe, Takatsune Shimizu, Shunsuke Shirozu, Hiroyuki Terakado. Association of family pharmacist continuity with patient-reported satisfaction in patients with metastatic cancer: a nationwide cross-sectional study. Journal of Pharmaceutical Health Care and Sciences. 2026
Akihito Nagahama, Atsunobu Sagara, Hayato Aki, Hiroki Yoshimura, Makoto Hiraide, Takatsune Shimizu, Motohiko Sano, Tetsuro Yumoto, Tomoo Hosoe, Kenji Tanaka. Effects of second generation antihistamines on daily driving with and without subtasks measured in a driving simulator. Discover Applied Sciences. 2025. 8. 2
Hitoshi Makabe, Yusuke Hamada, Michiko Narita, Kenichi Tanaka, Jion Takise, Risako Tatezuki, Nao Kawamura, Yukari Suda, Takatsune Shimizu, Naoko Kuzumaki, et al. Usefulness of zoledronic acid for the aggravated bone cancer and bone cancer pain. PAIN RESEARCH. 2025. 40. 1. 43-53
Jun Saito, Nobuyuki Onishi, Juntaro Yamasaki, Naoyoshi Koike, Yukie Hata, Kiyomi Kimura, Yuji Otsuki, Hiroyuki Nobusue, Oltea Sampetrean, Takatsune Shimizu, et al. Benzaldehyde suppresses epithelial-mesenchymal plasticity and overcomes treatment resistance in cancer by targeting the interaction of 14-3-3ζ with H3S28ph. British journal of cancer. 2025
國島綾花, 清水孝恒, 信末博行, 佐谷秀行, 福地由美, 武藤章弘. The critical roles of HIF-1α on in vivo tumorigenesis in osteosarcoma. 日本癌学会学術総会抄録集(Web). 2024. 83rd
福地由美, 國島綾花, 清水孝恒, 武藤章弘. The Potential of Graves’ Disease Mouse Model as a Model for Immune Checkpoint Inhibitor-Induced Thyroiditis. 日本癌学会学術総会抄録集(Web). 2024. 83rd
2001 - 2005 Keio University School of Medicine Graduate School of Medicine
1999 - 2001 Keio University School of Medicine Department of Internal Medicine
1993 - 1999 Keio University School of Medicine
Professional career (1)：
医学博士 (慶應義塾大学)
Work history (5)：
2012/06 - 現在 Keio University School of Medicine Division of Gene Regulation, Institute of Advanced Medical Research Visiting Associate Professor
2012/06 - 現在 Hoshi University Hoshi University
2007/02 - 2012/05 Keio University School of Medicine Division of Gene Regulation, Institute of Advanced Medical Research Assistant Professor
2005/05 - 2007/01 Kumamoto University Graduate School of Medical Sciences, Department of Tumor Genetics and Biology, Postdoctral Fellow
2005/04 - 2006/12 Keio University School of Medicine
Committee career (2)：
2020/04 - 現在 The Japanese Society for Clinical Molecular Morphology Councilor
2015/01 - 現在 Japanese Cancer Association Councilor
Awards (1)：
2018/09 - Japanese Society for Clinical Molecular Morphology Excellent Presentation Award
Association Membership(s) (7)：
日本薬学会
, American Association of Cancer Research
, THE JAPANESE CANCER ASSOCIATION
, THE JAPANESE SOCIETY OF INTERNAL MEDICINE
, Meguro Medical Association
, 東京内科医会
, 日本臨床分子形態学会
